CLINICAL AND THERAPEUTIC STUDIES OF HUMAN FILARIASIS

人类丝虫病的临床和治疗研究

• 批准号: 6160613
• 负责人: T B NUTMAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6160613
• 关键词: anthelmintics; clinical research; clinical trials; disease /disorder classification; enzyme linked immunosorbent assay; epidemiology; filariasis; human subject; human therapy evaluation; immunity; onchocerciasis; parasitic disease chemotherapy; parasitic disease diagnosis; parasitic diseases; pathologic process; polymerase chain reaction

The clinically based research in the Helminth Immunology Section has focused on three major themes: definition of clinical syndromes and the pathogenesis underlying them, chemotherapy and prevention of post-treatment adverse reactions, and new methods for diagnosis. Thus, the goals of this project are to give greater clinical definitions of the major filarial infections of humans (lymphatic filariasis, onchocerciasis, loiasis) to develop better means of diagnosing them (as many infections are cryptic and currently undiagnosable), and to develop optimal forms of treament for both individuals and affected populations.

蠕虫免疫科的临床研究 集中在三个主要主题：临床综合征的定义和 发病机制，化疗和预防， 治疗后的不良反应和新的诊断方法。因此，在本发明中， 该项目的目标是提供更多的临床定义， 人类的主要丝虫感染（淋巴丝虫病， 盘尾丝虫病，洛伊托），以发展更好的诊断手段（如 许多感染是神秘的，目前无法诊断），并发展 对个人和受影响人群的最佳治疗形式。