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MOLECULAR DEFINITION OF FILARIAL ANTIGENS

MOLECULAR DEFINITION OF FILARIAL ANTIGENS
丝虫抗原的分子定义
批准号：
3790780
负责人：
T B NUTMAN
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3790780
关键词：
Filarioidae Wuchereria filariasis helminthic antigen human subject immediate hypersensitivity microorganism genetics microorganism immunology nucleic acid probes recombinant DNA

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中文摘要
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英文摘要
The objectives of this project are to define and generate filarial proteins that are important in inducing parasite-specific immune responses in the human host and to understand, at a molecular level, the differences among related filarial species. Recombinant antigens and probes have been identified that: a) encode immunoreactive and potentially protective molecules of W. bancrofti; b) can distinguish among related filarial species; c) identify repeated segments of either the W. bancrofti genome or that of Loa loa; d) may be of potential diagnostic importance; and e) induce immediate hypersensitivity type responses in lymphatic filarial syndromes.
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MOLECULAR DEFINITION OF FILARIAL ANTIGENS
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