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PHYSOSTIGMINE AND ANALOGS

PHYSOSTIGMINE AND ANALOGS
毒扁豆碱及其类似物
批准号：
3876465
负责人：
A BROSSI
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3876465
关键词：
carbamates cholinesterase inhibitors drug design /synthesis /production drug metabolism oxazine physostigmine

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英文摘要
Novel carbamates of N(l)-norphysostigmine of the (-)-series were prepared. Both, the butyl- and the octyl-analog were found to be highly potent in vitro in inhibiting cholinesterases. Synthesis of (+)physovenine from intermediates of the physostigmine synthesis was accomplished. Synthesis of optically active material by phase-transfer induced chirality has been achieved. Synthesis of natural N(8)norphysostigmine from 5-methoxy-N-methyltryptamine has been initiated and led to (+)-N(8)-noreseroline methyl ether. Resolution by the phenylethylurea method is planned.
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