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PHYSOSTIGMINE AND ANALOGS

PHYSOSTIGMINE AND ANALOGS
毒扁豆碱及其类似物
批准号：
3941137
负责人：
A BROSSI
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3941137
关键词：
X ray crystallography analgesics carbamates chemical structure function cholinesterase inhibitors drug design /synthesis /production drug metabolism indoles isomer methylation physostigmine stereoisomer

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英文摘要
New carbamate analogs of (-)-physostigmine were prepared from (-)-eseroline and various isocyanates, including optically active 1- phenylethyl isocyanates. N-Benzylation of (-)-N1-noreseroline O- methylether prepared by total synthesis afforded N1- benzylnorphysostigmine, after O-demethylation and reaction with N-methylisocyanate, and N1-norphysostigmine after catalytic debenzylation over Pd-catalyst in methanol. A larger quantity of (+)-physostigmine was prepared by total synthesis, using for purification of intermediates and end product fumarate and salicylate salts and avoiding column chromatography.
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STUDIES REGARDING THE NEUROTOXIN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
STUDIES REGARDING THE NEUROTOXIN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
PHYSOSTIGMINE AND ANALOGS
NORTROPANE ALKALOIDS
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