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STUDIES REGARDING THE NEUROTOXIN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE

STUDIES REGARDING THE NEUROTOXIN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
关于神经毒素 1-甲基-4-苯基-1,2,3,6-四氢吡啶的研究
批准号：
3964164
负责人：
A BROSSI
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3964164
关键词：
MAO inhibitors Parkinson's disease analgesics antiadrenergic agents biotransformation brain metabolism chemical structure function chemical synthesis dopamine ferroxidase neurotoxins oxidation piperidine pyridine pyridinones toxin metabolism

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中文摘要
翻译
MPTP是铜氧化酶铜蓝蛋白的假底物，两者都是
英文摘要
MPTP is a pseudosubstrate for the copper oxidase ceruloplasmin, and both MPDP+ and MPP+ are produced. Incubation of MPTP with horseradish peroxidase only provided MPTP N-oxide. Oxidation of MPDP+ and MPP+ with potassium ferricyanide afforded a dihydropyridone and a pyridone respectively. MPTP analogs derived from prodine-type analgesics were found to be devoid of neurotoxic properties. A series of deuterated MPTP-analogs was prepared and their inhibitory effects on MAO B measured.
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STUDIES REGARDING THE NEUROTOXIN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
PHYSOSTIGMINE AND ANALOGS
NORTROPANE ALKALOIDS
ANALYTICAL REAGENTS FROM DIHYDROFLUORESCEIN
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