NORTROPANE ALKALOIDS

去甲烷生物碱

• 批准号: 3876469
• 负责人: A BROSSI
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3876469
• 关键词: alkaloids; chemical synthesis; medicinal plants; methylation; optics

Synthesis of Chinese nortropane alkaloid boagongteng A from Erycibe plants has been initiated from (+)-6-hydroxytropin-2-one. Optical resolution has been accomplished with camphersulfonic acids. Ndemethylation and N-benzylation afforded (+)-6-acetoxy-N- benzyltropin-2-one which will be used in the next step. N-Demethylation of tertiary amines with trichloroethyl chloroformate gives ditrichloroethyl carbonate as a by-product.

茅草属植物去甲托烷生物碱博公藤A的合成 由(+)-6-羟托品-2-酮引发。光学分辨率有 是用樟脑磺酸完成的。 N去甲基化和 N-苄基化得到 (+)-6-乙酰氧基-N-benzyltropin-2-one，这将是 在下一步中使用。叔胺的 N-去甲基化 氯甲酸三氯乙酯得到碳酸二三氯乙酯 副产品。