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CHEMISTRY AND METABOLISM OF QINGHAOSU, A CHINESE ANTIMALARIAL DRUG

CHEMISTRY AND METABOLISM OF QINGHAOSU, A CHINESE ANTIMALARIAL DRUG
国产抗疟药青蒿素的化学和代谢
批准号：
3918275
负责人：
A BROSSI
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3918275
关键词：
X ray crystallography antimalarial agents dimer drug design /synthesis /production drug screening /evaluation malaria pyrans sesquiterpenes

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中文摘要
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英文摘要
Structure of 11-epi-deoxyarteether formed from deoxyarteether and its alfa-isomer by treatment with acid in ethanol was established. It could be shown that this reaction proceeds via an intermediate vinylic ether. Treatment of deoxydihydroquinghaosu with toluene sulfonic acid in benzene afforded a dimer which was elucidated in its structure by an X-ray analysis. These compounds were made in connection with the WHO-program on arteether, an antimalarial prepared from the Chinese drug quinghaosu (artemisinin).
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STUDIES REGARDING THE NEUROTOXIN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
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