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PHYSOSTIGMINE AND ANALOGS

PHYSOSTIGMINE AND ANALOGS
毒扁豆碱及其类似物
批准号：
3840494
负责人：
A BROSSI
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3840494
关键词：
analog carbamates chemical structure cholinesterase inhibitors drug adverse effect drug screening /evaluation pharmacokinetics pharmacology physostigmine

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英文摘要
Several carbamates of the physostigmine and thiaphysovenine series are presently undergoing a secondary screening to measure half-life and toxicity. Patent applications to cover these compounds as anticholinesterase agents have been filed. An X-ray analysis of a biologically active and inactive representative suggest that the latter is sterically hindered and not capable for trans-carbamoylation of the enzyme.
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STUDIES REGARDING THE NEUROTOXIN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
STUDIES REGARDING THE NEUROTOXIN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
PHYSOSTIGMINE AND ANALOGS
NORTROPANE ALKALOIDS
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