NORTROPANE ALKALOIDS

去甲烷生物碱

• 批准号: 3855428
• 负责人: A BROSSI
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3855428
• 关键词: alkaloids; chemical synthesis; medicinal plants; methylation; optics

Efficient synthesis of several N-protected 6-acetoxynortropin-3-ones has been achieved. N-Benzyl-6-acetoxynortropin-3-one was converted into 6- acetoxynortropane. Bromination of 6-acetoxytropin-3-one and its N- protected noranalogs afforded mixtures of 2- and 4-brominated ketones.

几种N-保护的6-乙酰氧基去甲肾上腺素-3-酮的高效合成 已经实现了。将N-苄基-6-乙酰氧基去甲托品-3-酮转化为6-苯基-6-去甲肾上腺素 乙氧基去甲托烷。6-乙酰氧基托品-3-酮及其N-甲基-3-酮的溴化反应 受保护的降冰片类似物提供2-溴化酮和4-溴化酮的混合物。