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STUDIES REGARDING THE NEUROTOXIN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE

STUDIES REGARDING THE NEUROTOXIN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
关于神经毒素 1-甲基-4-苯基-1,2,3,6-四氢吡啶的研究
批准号：
4689175
负责人：
A BROSSI
金额：
$0.0万
依托单位：
NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/4689175
关键词：
MAO inhibitors antiadrenergic agents biotransformation brain metabolism chemical structure function chemical synthesis dopamine neurotoxins piperidine pyridine toxin metabolism

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相关文献

中文摘要
翻译
MPDP+已被认为是代谢物中的中间代谢物。 将MPTP转换为MPP+。 MPDP+在生理pH下水解 MPTP和MPP+。 MPTP、MPDP+和MPP+是 单胺氧化酶B，并且所有三种都抑制大鼠多巴胺摄取 突触体制备。 开发了MPDP+的新合成方法， 在MPTP的不同位置具有苯基的MPTP类似物 四氢吡啶环，并且具有N-烷基而不是N-甲基 组准备。 MPTP所显示的生物学效应并不 迄今为止制备的任何类似物都显示出了这一点。
英文摘要
MPDP+ has been recognized to be an intermediary metabolite in the conversion of MPTP into MPP+. MPDP+ disproportionates at physiological pH into MPTP and MPP+. MPTP, MPDP+ and MPP+ are inhibitors of monoamineoxidase B, and all three inhibit dopamine uptake in rat synaptosomal preparations. New synthesis of MPDP+ were developed and analogs of MPTP with the phenyl group at different positions of the tetrahydropyridine ring, and with N-alkyl groups instead of an N-methyl group were prepared. The biological effects demonstrated by MPTP were not shown by any of its analogs prepared thus far.
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STUDIES REGARDING THE NEUROTOXIN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
PHYSOSTIGMINE AND ANALOGS
NORTROPANE ALKALOIDS
ANALYTICAL REAGENTS FROM DIHYDROFLUORESCEIN