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PHYSOSTIGMINE AND ANALOGS

PHYSOSTIGMINE AND ANALOGS
毒扁豆碱及其类似物
批准号：
3964167
负责人：
A BROSSI
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3964167
关键词：
X ray crystallography analgesics chemical structure function cholinesterase inhibitors drug design /synthesis /production drug metabolism indoles isomer physostigmine stereoisomer

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英文摘要
Anticholinesterase activity of analogs of natural (-)-physostigmine, was measured. (-)-N-Methylphysostigmine was found to be much more potent, whereas unnatural (+)-physostigmine was about 125 times less potent. Fragmentation of (-)-physostigmine in refluxing hexanol afforded (-)-eseroline quantitatively. X-ray diffraction analysis showed rubreserine to contain equal parts of o-quinone and its zwitterion.
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