MYELOTOXICITY IN MICE CAUSED BY DRINKING MIXTURE OF GROUNDWATER CONTAMINANTS

饮用地下水污染物混合物引起的小鼠骨髓毒性

• 批准号: 3876865
• 负责人: H L HONG
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3876865
• 关键词: biological models; blood cell count; bone marrow disorder; cytotoxicity; environmental toxicology; ground water; hematopoiesis; hematopoietic stem cells; histopathology; industrial waste; laboratory mouse; radiation recovery; radiobiology; toxin metabolism; water drinking behavior; water pollution; whole body irradiation dosage

Studies concerning the health effects of groundwater contaminants have been focused primarily on cancer as an endpoint. In the present studies, bone marrow parameters were monitored in mice exposed to 0, 1, 5, and 10% of a chemical mixture in drinking water for 17 days or up to 32 weeks. The mixture consisted of 25 common groundwater contaminants frequently found near toxic waste dumps as determined by EPA surveys. Mice exposed to 5 and 10% of stock solution for 15.5 weeks showed suppression of granulocyte-macrophage progenitor cells and erythroid precursors with few or no effects on body weight, histopathology and peripheral blood counts. Mice were allowed to recover for 10 weeks at which time they received whole body irradiation. Previously chemical-treated mice were more sensitive to irradiation than untreated controls. Furthermore, synergistic effects of chemical and irradiation were demonstrated by continuing chemical exposure with multiple irradiation. The effect became more pronounced following multiple irradiation and the recovery of progenitor cells occurred more slowly. Thus, chemical exposure caused a significant residual marrow damage that was not apparent with routine hematological or pathological techniques, but could be demonstrated by subsequent irradiation. These results suggest that long-term exposure to highly contaminated groundwater may present a subtle risk to the hematopoietic stem cells.

关于地下水污染物对健康影响的研究