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CHEMISTRY AND METABOLISM OF QINGHAOSU, A CHINESE ANTIMALARIAL DRUG

CHEMISTRY AND METABOLISM OF QINGHAOSU, A CHINESE ANTIMALARIAL DRUG
国产抗疟药青蒿素的化学和代谢
批准号：
3941136
负责人：
A BROSSI
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3941136
关键词：
X ray crystallography antimalarial agents drug design /synthesis /production drug screening /evaluation injection /infusion malaria pyrans sesquiterpenes

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中文摘要
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英文摘要
A deoxyanalog of the Chinese antimalarial drug qinghaosu = artemisinin and deoxyanalogs of dihydroqinghaosu, arteether and its alfa isomer were prepared as analytical standards. Dihydroqinghaosu and deoxydihydroqinghaosu were characterized as highly fluorescent diacetyldihydrofluorescein esters, converted by exposure to ammonia vapors followed by iodine vapors, into red colored and highly visible dyes. Treatment of arteether and its alfa-isomer with hydrochloric acid in ethanol led to a new ethyl ether isomer with the methyl group at C-11 inverted as established by solid state X-ray diffraction analysis.
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STUDIES REGARDING THE NEUROTOXIN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
STUDIES REGARDING THE NEUROTOXIN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
PHYSOSTIGMINE AND ANALOGS
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