Molecular and cellular control of oocyte maturation in mammals

哺乳动物卵母细胞成熟的分子和细胞控制

• 批准号: G1001705-E01/1
• 负责人: John Carroll
• 金额: $ 231.52万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1001705-E01%2F1
• 关键词: Molecular; cellular; control; oocyte; maturation

The ability to produce a healthy fertile egg is essential for reproduction. Problems associated with the development of eggs are a major cause of infertility and early embryo loss (miscarriage). One of the reasons why eggs are so vulnerable is that they go through a specialised process known as meiosis. This process starts during foetal life and does not finish until after the egg is fertilized; more than 40 years later in some cases. Furthermore, women are born with all the eggs that will be available for her reproductive lifespan; no new eggs can be made. In meiosis the egg stops and starts at different stages but spends most of its life in a so-called ?dormant? state in the ovary. At some point the egg starts to grow increasing in diameter by 5 fold and in volume by about 300 fold to become one of the largest cells in the body (one-tenth of a millimetre across). Through all of this process the egg remains arrested in development and it is not until just before ovulation that the egg continues meiosis and halves the number of chromosomes. This meiotic division is prone to errors and is the single main reason why there is such a dramatic decrease in fertility as women get older, particularly over the age of 40. We are using mouse eggs to try to understand how meiosis works so that we can understand more about how to keep eggs arrested and healthy in the ovary and how they can go through the meiotic division without errors that cause poor quality embryos. Advances in our research are communicated in scientific journals, specialist websites and by press releases to the mainstream media. This way we aim to keep scientists, those with special interest and the public aware of our MRC funded research.

产生健康的受精卵的能力对繁殖至关重要。与卵子发育有关的问题是不孕不育和早期胚胎丢失（流产）的主要原因。卵子如此脆弱的原因之一是它们经历了一个被称为减数分裂的特殊过程。这个过程从胎儿时期开始，直到卵子受精后才结束；在某些情况下是40多年后。此外，女性出生时就拥有在其生殖寿命中可用的所有卵子；没有新的鸡蛋可以产生。在减数分裂中，卵子在不同的阶段停止和开始，但大部分时间都处于所谓的“休眠”状态。卵巢的状态。在某种程度上，卵子开始生长，直径增加5倍，体积增加约300倍，成为身体中最大的细胞之一（直径为十分之一毫米）。在所有这些过程中，卵子的发育一直处于停滞状态，直到排卵前，卵子才继续减数分裂，染色体数量减半。这种减数分裂很容易出错，也是女性年龄增长，尤其是40岁以上女性生育能力急剧下降的唯一主要原因。我们正在用老鼠的卵子试图了解减数分裂是如何工作的，这样我们就能更多地了解如何在卵巢中保持卵子的健康，以及它们如何在减数分裂过程中不会出现导致胚胎质量差的错误。我们的研究进展通过科学期刊、专业网站和向主流媒体发布的新闻稿进行交流。通过这种方式，我们的目标是让科学家、有特殊兴趣的人以及公众了解我们MRC资助的研究。