GASP--A SOFTWARE TOOL FOR METHODOLOGIC DEVELOPMENT IN STATISTICAL GENETICS

GASP——统计遗传学方法开发的软件工具

• 批准号: 6109036
• 负责人: ALEXANDER F WILSON
• 金额: --
• 依托单位: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6109036
• 关键词: computer program /software; computer simulation; computer system design /evaluation; family genetics; genetic models; human data; statistics /biometry

Development of computer software for statistical genetic analysis can be facilitated by the availability of software tools that can be used to 1) verify the algorithms, 2) determine empirical type I error rates, 3) determine the power of a test, and 4) to determine the robustness of a test with respect to failures of underlying assumptions. The Genometric Analysis Simulation Program (G.A.S.P.) is a software tool that can generate samples of family data based on user-specified models. Both trait and marker data can be generated. Data generated can be as simple as a single sample of random individuals, or as complex as thousands of samples of extended families with traits based on a linear combination of major locus, polygenic, common sibship environment and covariate components.

开发计算机统计软件 遗传分析可以通过软件的可用性来促进 可用于1）验证算法，2）确定 经验I型错误率，3）确定测试的功效，以及4） 为了确定测试对于以下故障的鲁棒性， 基本假设。基因分析模拟 程序（G.A.S.P.）是一个软件工具，可以生成样本， 基于用户指定模型的族数据。性状和标记 可以生成数据。生成的数据可以像单个 随机个体的样本，或复杂到数千个 样本的扩展家庭的性状基于线性 主基因座、多基因、共同亲缘组合 环境和协变量成分。