STRUCTURE OF CTLA 4, T CELL CO STIMULATORY FACTOR

MHC抗原呈递的结构基础代表了 免疫学的主要焦点。我们现正进行以下研究： 参与T细胞识别的T细胞分子 旨在理解规则，通过这些规则？？T细胞受体 分子与MHC分子中结合的多肽相互作用 引导T细胞活化的后续事件。除 MHC和T细胞受体，CTLA-4和B7等多个蛋白 对于调节T细胞的反应是必不可少的。我们已经准备好了 共刺激因子CTLA-4的晶体并收集了 X9B到2.0E分辨率的出色数据。我们目前使用的是 X9B站具有出色的可调性，可通过以下方式解决此结构 使用常规重原子衍生物和硒蛋氨酸的MAD 换人。

The structural basis of MHC antigen presentation represents one of the major focuses of immunology. We are currently pursuing studies on molecules of the T cell that are involved in T cell recognition directed at understanding the rules by which the ?? T cell receptor molecules interact with the peptide bound in the MHC molecule and the subsequent events that direct T-cell activation. In addition to the MHC and T-cell receptor, a number of proteins such as CTLA-4 and B7 are essential for modulating the T-cell response. We have prepared crystals of the co-stimulatory factor CTLA-4 and have collected excellent data at X9B to 2.0E resolution. We are currently using the outstanding tunability at the X9B station to solve this structure by MAD using conventional heavy atom derivatives and selenomethionine substitution.