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STRUCTURE OF CTLA 4, T CELL CO STIMULATORY FACTOR

STRUCTURE OF CTLA 4, T CELL CO STIMULATORY FACTOR
CTLA 4、T 细胞 CO 刺激因子的结构
批准号：
6205795
负责人：
STEVE ALMO
金额：
$0.0万
依托单位：
ALBERT EINSTEIN COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-09-01 至 2000-08-31
来源：
https://reporter.nih.gov/project-details/6205795
关键词：
biological products biomedical resource enzymes spectrometry synchrotrons

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英文摘要
A small crystal of AOP-RANTES (0.1 X 0.05 X 0.05 mm3) was rapidly cooled in the nitrogen stream and diffracted to 1.6 A resolution in 30 sec exposures. 159 frames of 1 degree oscillation were collected at 0.98 A wavelength. This resulted in a complete data set of excellent quality from 20 to 1.6 A resolution, with 99.8% overall completeness, I/sigma(I) of 31.8, and 11-fold redundancy. The structure was solved by molecular replacement, using the structure of Met-RANTES as a search model, and has been refined with the final R-factor of 16.7%, and a final R-free of 24.1%.
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