FLUORESCENCE EEM SPECTROSCOPY FOR DETECTION OF DYSPLASIA IN EPITHELIAL TISSUES

我们已经开发了体内EEM系统，可以收集10 用10种不同光源激发的荧光光谱， 来自同一组织的漫反射光谱在小于 一下 该系统目前被用于研究癌前病变 巴雷特食管和结肠的变化 到目前为止，我们已经检查了 近55名患者在巴雷特氏症中接受发育不良监测， 食道 该系统也被用于布里格姆和妇女的 结肠腺瘤性息肉和发育不良研究医院。 的 快速EEM系统提供了丰富的荧光信息， 使用基于模型的方法和主成分进行分析 分析方法

We have developed in vivo EEM system which can collect 10 fluorescence spectra excited with 10 different light sources and diffuse reflectance spectra from the same tissue in less than a second. This system is currently being used to study precancerous changes in Barrett's esophagus and colon. So far we have examined nearly 55 patients undergoing surveillance for dysplasia in Barrett's esophagus. The system is also being used at the Brigham and Women's Hospital for studying adenomatous polyps and dysplasia in colon. The wealth of fluorescence information provided by rapid EEM system is being analyzed using model based approach and principal component analysis approach.