CHARACTERIZATION OF OPTICAL FIBER PROBES FOR IN VIVO RAMAN SPECTROSCOPY

用于体内拉曼光谱的光纤探针的表征

• 批准号: 6314195
• 负责人: RAMASAMY MANOHARAN
• 金额: $ 1.38万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-01 至 2001-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6314195
• 关键词: biomedical resource; cardiovascular system; human tissue; surgery; technology /technique

In Vivo Raman spectroscopy requires use of optical fiber probes for laser light delivery and collection of return Raman signals. Fluorescence and Raman background generated in the silica fibers hinder measurement of Raman spectra from biological tissue samples in vivo. We are developing and evaluating various optical fiber probes in which laser band pass filter and cut-off filters are incorporated. Dielectric band-pass filter incorporated in the excitation fiber eliminates background generated in the fiber and allow only the excitation light to illuminate the tissues. A dielectric cut-off filter incorporated in the collection fibers blocks the laser light from entering the fiber and passes only the Raman scattered light emitted by tissues. We are working closely with Visionex and currently evaluating the performance of their probes. Parameters such as the transmission wavelength, efficiency of the filters, the extent to which the fiber background is suppressed, and also the compatibility of these for clinical measurements are being evaluated.

体内拉曼光谱需要使用光纤探头 用于激光传输和返回拉曼信号的收集。 二氧化硅纤维中产生的荧光和拉曼背景 阻碍生物组织样品拉曼光谱的测量 体内。 我们正在开发和评估各种光纤探头 其中包含激光带通滤波器和截止滤波器。 激励光纤中包含电介质带通滤波器 消除了光纤中产生的背景，只允许 激发光照亮组织。 介电截止 收集纤维中包含的过滤器可阻挡激光 进入光纤并仅通过拉曼散射光 由组织排出。 我们与 Visionex 密切合作， 目前正在评估他们的探测器的性能。 参数如 作为传输波长、滤光片效率、范围 纤维背景被抑制，并且 正在评估这些临床测量的兼容性。