CHARACTERIZATION OF OPTICAL FIBER PROBES FOR IN VIVO RAMAN SPECTROSCOPY

体内拉曼光谱需要使用光纤探针 用于激光传输和收集返回的拉曼信号。 石英光纤中产生的荧光和拉曼背景 生物组织样品拉曼光谱受阻测量 vivo. 我们正在开发和评估各种光纤探头 其中结合了激光带通滤波器和截止滤波器。 介质带通滤波器纳入激发光纤 消除了光纤中产生的背景， 激发光照射组织。 电介质截止 收集光纤中包含的滤光器阻挡激光 并且仅通过拉曼散射光 由组织发出。 我们正在与Visionex密切合作， 正在评估他们的探测器的性能 参数 由于透射波长、滤波器的效率、 纤维背景被抑制， 正在评估这些用于临床测量的兼容性。

In Vivo Raman spectroscopy requires use of optical fiber probes for laser light delivery and collection of return Raman signals. Fluorescence and Raman background generated in the silica fibers hinder measurement of Raman spectra from biological tissue samples in vivo. We are developing and evaluating various optical fiber probes in which laser band pass filter and cut-off filters are incorporated. Dielectric band-pass filter incorporated in the excitation fiber eliminates background generated in the fiber and allow only the excitation light to illuminate the tissues. A dielectric cut-off filter incorporated in the collection fibers blocks the laser light from entering the fiber and passes only the Raman scattered light emitted by tissues. We are working closely with Visionex and currently evaluating the performance of their probes. Parameters such as the transmission wavelength, efficiency of the filters, the extent to which the fiber background is suppressed, and also the compatibility of these for clinical measurements are being evaluated.