COMBINED RAMAN & FLUORESCENCE METHODS FOR BREAST CANCER DETECTION & IMAGING

组合拉曼

• 批准号: 6314202
• 负责人: RAMASAMY MANOHARAN
• 金额: $ 1.38万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-01 至 2001-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6314202
• 关键词: biomedical equipment development; biomedical resource; female; human subject; human tissue; infrared radiation; lasers; spectrometry; technology /technique

We are developing two optical methods based on near infrared Raman spectroscopy and fluorescence photon migration for breast cancer diagnosis and imaging. Raman spectroscopy, an in situ technique for histochemical analysis, can be implemented via a fiber optic needle probe inserted into breast as part of needle aspiration or core biopsy. Fluorescence photon migration is being developed as an optical tomographic technique for localizing lesions. We envision that the two techniques can be integrated, with fluorescence imaging first to used to localize a suspicious lesion, and Raman information, obtained by passing a fiber optic probe through a biopsy needle, then used for accurate diagnosis. In the current year, we demonstrated the ability of Raman to classify accurately normal, benign, and malignant tissues by utilizing 830 nm light. We also showed that photon migration imaging can be used to localize accurately small fluorescent objects imbedded in a thick trubid m edium with realistic optical properties, thus demonstrating the potential of this technique for optical imaging.

我们正在开发两种基于近红外拉曼的光学方法 乳腺癌的光谱学和荧光光子迁移 诊断和影像学。 拉曼光谱，一种原位技术 组织化学分析，可以通过光纤针进行 作为针吸或核心的一部分插入乳房的探针 活检。 荧光光子迁移正在被开发为一种 用于定位病变的光学断层扫描技术。 我们设想 这两种技术可以通过荧光成像集成 首先用于定位可疑病变和拉曼信息， 通过将光纤探头穿过活检针获得，然后 用于准确诊断。 今年，我们展示了 拉曼准确分类正常、良性和恶性的能力 利用 830 nm 光对组织进行分析。 我们还展示了光子 迁移成像可用于精确定位小荧光 物体嵌入厚实的浑浊介质中，具有逼真的光学效果 特性，从而证明了该技术的潜力 光学成像。