Epigenetic regulation by PKC-theta in human breast cancer stem cells.
Epigenetic regulation by PKC-theta in human breast cancer stem cells.
批准号:
nhmrc : GNT1105409
负责人:
Prof David Jans
金额:
$81.81万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2016
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2016-01-01 至 --
中文摘要
点击翻译按钮获取中文摘要
英文摘要
Treating women with advanced breast cancer is difficult, and new drugs are needed to kill the cancer stem cells that cause recurrence. We think that a newly discovered protein, PKC-θ, plays an important role in recurring breast cancer and can be targeted using novel ‘epigenetic’ drugs. Here, we will use cutting-edge DNA techniques to learn how this protein controls how cancer cells grow and produce the necessary data to show that targeting this protein is likely to be effective in real patients.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Nuclear transport in stress
-
批准号:DP190101966
-
项目类别:Discovery Projects
-
资助金额:$37.21万
-
财政年份:2019
-
负责人:Prof David Jans
-
依托单位:
Nuclear Transport in Health and Disease; Towards Therapeutics
-
批准号:nhmrc : GNT1103050
-
项目类别:Research Fellowships
-
资助金额:$85.2万
-
财政年份:2016
-
负责人:Prof David Jans
-
依托单位:
Nuclear Transport in Health and Disease; Towards Therapeutics
-
批准号:nhmrc : 1103050
-
项目类别:Research Fellowships
-
资助金额:$58.74万
-
财政年份:2016
-
负责人:Prof David Jans
-
依托单位:
Epigenetic regulation by PKC-theta in human breast cancer stem cells.
-
批准号:nhmrc : 1105409
-
项目类别:Project Grants
-
资助金额:$56.28万
-
财政年份:2016
-
负责人:Prof David Jans
-
依托单位:
Transcription factor nuclear residency as a driver of gene expression
-
批准号:DP130100804
-
项目类别:Discovery Projects
-
资助金额:$25.6万
-
财政年份:2013
-
负责人:Prof David Jans
-
依托单位:
Respiratory Syncytial Virus Matrix Protein-Host Protein Interactions as Targets for Therapeutics
-
批准号:nhmrc : 1043511
-
项目类别:Project Grants
-
资助金额:$45.8万
-
财政年份:2013
-
负责人:Prof David Jans
-
依托单位:
The Essential Nuclear Transporter Importin 13; key role in brain and testis
-
批准号:nhmrc : 1022206
-
项目类别:Project Grants
-
资助金额:$40.88万
-
财政年份:2012
-
负责人:Prof David Jans
-
依托单位:
Rhinovirus protease subcellular trafficking and host cell targets; relevance to asthma exacerbation and vaccine approaches
-
批准号:nhmrc : 1027312
-
项目类别:Project Grants
-
资助金额:$38.81万
-
财政年份:2012
-
负责人:Prof David Jans
-
依托单位:
Enhanced nuclear transport in transformed cells; implications for cancer treatment
-
批准号:nhmrc : 1032143
-
项目类别:Project Grants
-
资助金额:$41.92万
-
财政年份:2012
-
负责人:Prof David Jans
-
依托单位:
Regulation of nucleocytoplasmic transport; role in health and disease
-
批准号:nhmrc : 1002486
-
项目类别:Research Fellowships
-
资助金额:$54.88万
-
财政年份:2011
-
负责人:Prof David Jans
-
依托单位:
New targets for antiviral therapies
-
批准号:DP110101749
-
项目类别:Discovery Projects
-
资助金额:$29.56万
-
财政年份:2011
-
负责人:Prof David Jans
-
依托单位:
Regulation of subcellular localisation of respiratory syncytial virus M protein: implications for pathology
-
批准号:nhmrc : 606407
-
项目类别:NHMRC Project Grants
-
资助金额:$38.69万
-
财政年份:2010
-
负责人:Prof David Jans
-
依托单位:
Nuclear functions of Dengue NS5 protein: role in disease
-
批准号:nhmrc : 606409
-
项目类别:NHMRC Project Grants
-
资助金额:$49.14万
-
财政年份:2010
-
负责人:Prof David Jans
-
依托单位:
Novel microtubule association sequences from rabies virus; subversion of antiviral responses and use in drug delivery
-
批准号:nhmrc : 545838
-
项目类别:NHMRC Project Grants
-
资助金额:$35.32万
-
财政年份:2009
-
负责人:Prof David Jans
-
依托单位:
Negative regulators of nuclear import; potential links to cancer
-
批准号:nhmrc : 491055
-
项目类别:NHMRC Project Grants
-
资助金额:$33.06万
-
财政年份:2008
-
负责人:Prof David Jans
-
依托单位:
Role of nucleocytoplasmic trafficking of Matrix protein in RSV infection
-
批准号:nhmrc : 436611
-
项目类别:NHMRC Project Grants
-
资助金额:$33.01万
-
财政年份:2007
-
负责人:Prof David Jans
-
依托单位:
The tumour cell-specific nuclear targeting properties of chicken anaemia virus VP-3: potential for anti-tumour therapy
-
批准号:nhmrc : 436614
-
项目类别:NHMRC Project Grants
-
资助金额:$31.02万
-
财政年份:2007
-
负责人:Prof David Jans
-
依托单位:
Role of the microtubule network in nuclear transport: potential use in gene delivery
-
批准号:nhmrc : 384107
-
项目类别:NHMRC Project Grants
-
资助金额:$32.79万
-
财政年份:2006
-
负责人:Prof David Jans
-
依托单位:
Research Fellowship - Grant ID:384105
-
批准号:nhmrc : 384105
-
项目类别:NHMRC Research Fellowships
-
资助金额:$50.09万
-
财政年份:2006
-
负责人:Prof David Jans
-
依托单位:
Engineered histones as DNA carriers with application in therapeutic gene delivery
-
批准号:nhmrc : 284205
-
项目类别:NHMRC Project Grants
-
资助金额:$27.86万
-
财政年份:2004
-
负责人:Prof David Jans
-
依托单位:
国内基金
海外基金
登录
查看更多内容
糖尿病ED中成纤维细胞衰老调控内皮细胞线粒体稳态失衡的机制研究
-
批准号:82371634
-
项目类别:面上项目
-
资助金额:49.00万元
-
批准年份:2023
-
负责人:赵福军
-
依托单位:
PRNP调控巨噬细胞M2极化并减弱吞噬功能促进子宫内膜异位症进展的机制研究
-
批准号:82371651
-
项目类别:面上项目
-
资助金额:49.00万元
-
批准年份:2023
-
负责人:赵栋
-
依托单位:
CBP/p300-HADH轴在基础胰岛素分泌调节中的作用和机制研究
-
批准号:82370798
-
项目类别:面上项目
-
资助金额:49.00万元
-
批准年份:2023
-
负责人:王晓
-
依托单位:
精氨酸调控骨髓Tregs稳态在脓毒症骨髓功能障碍中的作用研究
-
批准号:82371770
-
项目类别:面上项目
-
资助金额:49.00万元
-
批准年份:2023
-
负责人:宁铂涛
-
依托单位:
Got2基因对浆细胞样树突状细胞功能的调控及其在系统性红斑狼疮疾病中的作用研究
-
批准号:82371801
-
项目类别:面上项目
-
资助金额:47.00万元
-
批准年份:2023
-
负责人:周海波
-
依托单位:
TIPE2调控巨噬细胞M2极化改善睑板腺功能障碍的作用机制研究
-
批准号:82371028
-
项目类别:面上项目
-
资助金额:49.00万元
-
批准年份:2023
-
负责人:赵慧
-
依托单位:
亚低温调控颅脑创伤急性期神经干细胞Mpc2/Lactate/H3K9lac通路促进神经修复的研究
-
批准号:82371379
-
项目类别:面上项目
-
资助金额:49.00万元
-
批准年份:2023
-
负责人:冯军峰
-
依托单位:
PfAP2-R介导的PfCRT转录调控在恶性疟原虫对喹啉类药物抗性中的作用及机制研究
-
批准号:82372275
-
项目类别:面上项目
-
资助金额:49.00万元
-
批准年份:2023
-
负责人:刘耀宝
-
依托单位:
α-酮戊二酸调控ACMSD介导犬尿氨酸通路代谢重编程在年龄相关性听力损失中的作用及机制研究
-
批准号:82371150
-
项目类别:面上项目
-
资助金额:49.00万元
-
批准年份:2023
-
负责人:侯书乐
-
依托单位:
mPFC-VTA-NAc多巴胺能投射调控丙泊酚麻醉—觉醒的机制研究
-
批准号:82371284
-
项目类别:面上项目
-
资助金额:49.00万元
-
批准年份:2023
-
负责人:许涛
-
依托单位: