Nuclear functions of Dengue NS5 protein: role in disease
Nuclear functions of Dengue NS5 protein: role in disease
批准号:
nhmrc : 606409
负责人:
Prof David Jans
金额:
$49.14万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2010
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2010-01-01 至 2012-12-31
中文摘要
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英文摘要
Our work indicates that the NS5 protein from Dengue virus (DV) has distinct sequences that enable it to traffic into and out of the host cell nucleus to exert pathogenic effects on transcription and thereby impair the host cell anti-viral and immune responses. We aim to characterise these properties in detail, and demonstrate their importance to DV pathogenicity using a novel animal model of the disease.
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Epigenetic regulation by PKC-theta in human breast cancer stem cells.
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The tumour cell-specific nuclear targeting properties of chicken anaemia virus VP-3: potential for anti-tumour therapy
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依托单位:
Role of the microtubule network in nuclear transport: potential use in gene delivery
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Research Fellowship - Grant ID:384105
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Engineered histones as DNA carriers with application in therapeutic gene delivery
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依托单位:
国内基金
海外基金
数学物理中精确可解模型的代数方法
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批准号:11771015
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项目类别:面上项目
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资助金额:48.0万元
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批准年份:2017
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负责人:Oleksiy Zhedanov
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依托单位: