The Essential Nuclear Transporter Importin 13; key role in brain and testis

重要的核转运蛋白导入13；

• 批准号: nhmrc : 1022206
• 负责人: Prof David Jans
• 金额: $ 40.88万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/essential-nuclear-transporter-brain-testis/110173
• 关键词: Essential; Nuclear; Transporter; Importin; 13

Transport into and out of the nucleus, the control centre of cells, is critical for cell function in complex organisms such as mammals. The present proposal seeks to further understanding of a novel molecule mediating nuclear transport that has a novel inhibitory form in the testis, and important roles in the lung and nervous system. The results should help basic understanding of this molecule, and relate to disease conditions such as X-linked mental retardation and childhood asthma.

细胞核是细胞的控制中心，进出细胞核的运输对于哺乳动物等复杂生物体的细胞功能至关重要。目前的建议旨在进一步了解一种新的分子介导的核运输，具有一种新的抑制形式，在睾丸，在肺和神经系统的重要作用。这些结果应该有助于对这种分子的基本理解，并与X连锁精神发育迟滞和儿童哮喘等疾病有关。