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Negative regulators of nuclear import; potential links to cancer

Negative regulators of nuclear import; potential links to cancer
核进口的负面监管;
批准号:
nhmrc : 491055
负责人:
Prof David Jans
金额:
$33.06万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2010-12-31

项目摘要

项目成果

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中文摘要
翻译
蛋白质进入细胞核对哺乳动物细胞功能至关重要,与发育过程和癌症密切相关。我们已经确定了一类新的分子-核输入负调节因子-其功能是阻止细胞周期凋亡的关键调节因子进入细胞核,并因此与癌症有潜在的联系。我们建议确定它们的作用机制,由细胞信号调节,以及这对细胞功能-癌症的重要性。
英文摘要
Trafficking of proteins into the nucleus is critical to mammalian cell function, relating strongly to developmental processes and cancer. We have identified a new class of molecule - negative regulators of nuclear import - that function to prevent entry into the nucleus of key regulators of the cell cycle-apoptosis, and have a potential link thereby to cancer. We propose to determine their mechanism of action, modulation by cellular signals, and how important this is to cell function-cancer.
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Nuclear transport in stress
  • 批准号:
    DP190101966
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $37.21万
  • 财政年份:
    2019
  • 负责人:
    Prof David Jans
  • 依托单位:
Nuclear Transport in Health and Disease; Towards Therapeutics
  • 批准号:
    nhmrc : GNT1103050
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $85.2万
  • 财政年份:
    2016
  • 负责人:
    Prof David Jans
  • 依托单位:
Epigenetic regulation by PKC-theta in human breast cancer stem cells.
  • 批准号:
    nhmrc : GNT1105409
  • 项目类别:
    Project Grants
  • 资助金额:
    $81.81万
  • 财政年份:
    2016
  • 负责人:
    Prof David Jans
  • 依托单位:
Nuclear Transport in Health and Disease; Towards Therapeutics
  • 批准号:
    nhmrc : 1103050
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $58.74万
  • 财政年份:
    2016
  • 负责人:
    Prof David Jans
  • 依托单位:
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