Regulation of subcellular localisation of respiratory syncytial virus M protein: implications for pathology

呼吸道合胞病毒 M 蛋白亚细胞定位的调节：对病理学的影响

• 批准号: nhmrc : 606407
• 负责人: Prof David Jans
• 金额: $ 38.69万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-subcellular-localisation-implications-pathology/100576
• 关键词: Regulation; subcellular; localisation; respiratory; syncytial

Respiratory syncytial virus (RSV) is the major cause of viral pneumonia in infants and the elderly, causing more deaths in winter than influenza. We have observed RSV M protein in the nucleus of infected host cells where it inhibits host cell transcription. We propose to investigate the regulation of nuclear localisation of M by phosphorylation and binding to cellular factors and its importance to RSV pathogenesis. The results will relate strongly to future drug and vaccine development.

呼吸道合胞病毒（RSV）是婴儿和老年人病毒性肺炎的主要原因，在冬季造成的死亡人数比流感还要多。我们在受感染宿主细胞的细胞核中观察到 RSV M 蛋白，它抑制宿主细胞转录。我们建议研究 M 通过磷酸化和与细胞因子结合对核定位的调节及其对 RSV 发病机制的重要性。结果将与未来的药物和疫苗开发密切相关。