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Regulation of subcellular localisation of respiratory syncytial virus M protein: implications for pathology

Regulation of subcellular localisation of respiratory syncytial virus M protein: implications for pathology
呼吸道合胞病毒 M 蛋白亚细胞定位的调节:对病理学的影响
批准号:
nhmrc : 606407
负责人:
Prof David Jans
金额:
$38.69万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2010
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2010-01-01 至 2012-12-31

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中文摘要
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英文摘要
Respiratory syncytial virus (RSV) is the major cause of viral pneumonia in infants and the elderly, causing more deaths in winter than influenza. We have observed RSV M protein in the nucleus of infected host cells where it inhibits host cell transcription. We propose to investigate the regulation of nuclear localisation of M by phosphorylation and binding to cellular factors and its importance to RSV pathogenesis. The results will relate strongly to future drug and vaccine development.
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Nuclear transport in stress
  • 批准号:
    DP190101966
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $37.21万
  • 财政年份:
    2019
  • 负责人:
    Prof David Jans
  • 依托单位:
Nuclear Transport in Health and Disease; Towards Therapeutics
  • 批准号:
    nhmrc : GNT1103050
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $85.2万
  • 财政年份:
    2016
  • 负责人:
    Prof David Jans
  • 依托单位:
Epigenetic regulation by PKC-theta in human breast cancer stem cells.
  • 批准号:
    nhmrc : GNT1105409
  • 项目类别:
    Project Grants
  • 资助金额:
    $81.81万
  • 财政年份:
    2016
  • 负责人:
    Prof David Jans
  • 依托单位:
Nuclear Transport in Health and Disease; Towards Therapeutics
  • 批准号:
    nhmrc : 1103050
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $58.74万
  • 财政年份:
    2016
  • 负责人:
    Prof David Jans
  • 依托单位:
国内基金
海外基金
NSCLC细胞的EGFR、E-cad亚细胞定位与曲古抑菌素A逆转EGFR-TKI耐药的机制研究
  • 批准号:
    81101771
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    23.0万元
  • 批准年份:
    2011
  • 负责人:
    项轶
  • 依托单位: