Nuclear transport in stress

应激状态下的核运输

• 批准号: DP190101966
• 负责人: Prof David Jans
• 金额: $ 37.21万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190101966
• 关键词: Nuclear; transport; stress

This project aims to provide key new insights into cell resistance to stress centred on subcellular transport in stress. Environmental stress in its various forms results in the breakdown of cellular functions such as conventional transport into and out of the host cell nucleus. This project will examine a nuclear transporter that has the ability to remain active in stress. Results will establish a platform for stress biology research by the evaluation of nuclear transport in stress in cellular and in-vivo models, and its impact on cell fate. These outcomes will have broad-reaching benefits for enacting climate change responses as well as enhancing Australia’s international collaborative network and providing research training opportunities.

该项目旨在提供关键的新见解细胞抵抗压力集中在亚细胞运输在压力。各种形式的环境应激导致细胞功能的破坏，如进出宿主细胞核的常规运输。这个项目将研究一种核转运蛋白，它有能力在压力下保持活性。研究结果将通过在细胞和体内模型中评估胁迫下核转运及其对细胞命运的影响，为胁迫生物学研究建立一个平台。这些成果将对制定气候变化应对措施、加强澳大利亚的国际合作网络和提供研究培训机会产生广泛的好处。