Nuclear transport in stress
Nuclear transport in stress
批准号:
DP190101966
负责人:
Prof David Jans
金额:
$37.21万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2019
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2019-01-01 至 2022-06-30
中文摘要
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英文摘要
This project aims to provide key new insights into cell resistance to stress centred on subcellular transport in stress. Environmental stress in its various forms results in the breakdown of cellular functions such as conventional transport into and out of the host cell nucleus. This project will examine a nuclear transporter that has the ability to remain active in stress. Results will establish a platform for stress biology research by the evaluation of nuclear transport in stress in cellular and in-vivo models, and its impact on cell fate. These outcomes will have broad-reaching benefits for enacting climate change responses as well as enhancing Australia’s international collaborative network and providing research training opportunities.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Nuclear Transport in Health and Disease; Towards Therapeutics
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批准号:nhmrc : GNT1103050
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项目类别:Research Fellowships
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资助金额:$85.2万
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财政年份:2016
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负责人:Prof David Jans
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依托单位:
Epigenetic regulation by PKC-theta in human breast cancer stem cells.
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批准号:nhmrc : GNT1105409
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项目类别:Project Grants
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资助金额:$81.81万
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财政年份:2016
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负责人:Prof David Jans
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依托单位:
Nuclear Transport in Health and Disease; Towards Therapeutics
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批准号:nhmrc : 1103050
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项目类别:Research Fellowships
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资助金额:$58.74万
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财政年份:2016
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负责人:Prof David Jans
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依托单位:
Epigenetic regulation by PKC-theta in human breast cancer stem cells.
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批准号:nhmrc : 1105409
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项目类别:Project Grants
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资助金额:$56.28万
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财政年份:2016
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负责人:Prof David Jans
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依托单位:
Transcription factor nuclear residency as a driver of gene expression
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批准号:DP130100804
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项目类别:Discovery Projects
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资助金额:$25.6万
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财政年份:2013
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负责人:Prof David Jans
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依托单位:
Respiratory Syncytial Virus Matrix Protein-Host Protein Interactions as Targets for Therapeutics
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批准号:nhmrc : 1043511
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项目类别:Project Grants
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资助金额:$45.8万
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财政年份:2013
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负责人:Prof David Jans
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依托单位:
The Essential Nuclear Transporter Importin 13; key role in brain and testis
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批准号:nhmrc : 1022206
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项目类别:Project Grants
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资助金额:$40.88万
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财政年份:2012
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负责人:Prof David Jans
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依托单位:
Rhinovirus protease subcellular trafficking and host cell targets; relevance to asthma exacerbation and vaccine approaches
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批准号:nhmrc : 1027312
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项目类别:Project Grants
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资助金额:$38.81万
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财政年份:2012
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负责人:Prof David Jans
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依托单位:
Enhanced nuclear transport in transformed cells; implications for cancer treatment
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批准号:nhmrc : 1032143
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项目类别:Project Grants
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资助金额:$41.92万
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财政年份:2012
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负责人:Prof David Jans
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依托单位:
Regulation of nucleocytoplasmic transport; role in health and disease
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批准号:nhmrc : 1002486
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项目类别:Research Fellowships
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资助金额:$54.88万
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财政年份:2011
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负责人:Prof David Jans
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依托单位:
New targets for antiviral therapies
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批准号:DP110101749
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项目类别:Discovery Projects
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资助金额:$29.56万
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财政年份:2011
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负责人:Prof David Jans
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依托单位:
Regulation of subcellular localisation of respiratory syncytial virus M protein: implications for pathology
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批准号:nhmrc : 606407
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项目类别:NHMRC Project Grants
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资助金额:$38.69万
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财政年份:2010
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负责人:Prof David Jans
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依托单位:
Nuclear functions of Dengue NS5 protein: role in disease
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批准号:nhmrc : 606409
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项目类别:NHMRC Project Grants
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资助金额:$49.14万
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财政年份:2010
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负责人:Prof David Jans
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依托单位:
Novel microtubule association sequences from rabies virus; subversion of antiviral responses and use in drug delivery
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批准号:nhmrc : 545838
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项目类别:NHMRC Project Grants
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资助金额:$35.32万
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财政年份:2009
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负责人:Prof David Jans
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依托单位:
Negative regulators of nuclear import; potential links to cancer
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批准号:nhmrc : 491055
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项目类别:NHMRC Project Grants
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资助金额:$33.06万
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财政年份:2008
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负责人:Prof David Jans
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依托单位:
Role of nucleocytoplasmic trafficking of Matrix protein in RSV infection
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批准号:nhmrc : 436611
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项目类别:NHMRC Project Grants
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资助金额:$33.01万
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财政年份:2007
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负责人:Prof David Jans
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依托单位:
The tumour cell-specific nuclear targeting properties of chicken anaemia virus VP-3: potential for anti-tumour therapy
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批准号:nhmrc : 436614
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项目类别:NHMRC Project Grants
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资助金额:$31.02万
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财政年份:2007
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负责人:Prof David Jans
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依托单位:
Role of the microtubule network in nuclear transport: potential use in gene delivery
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批准号:nhmrc : 384107
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项目类别:NHMRC Project Grants
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资助金额:$32.79万
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财政年份:2006
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负责人:Prof David Jans
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依托单位:
Research Fellowship - Grant ID:384105
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批准号:nhmrc : 384105
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项目类别:NHMRC Research Fellowships
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资助金额:$50.09万
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财政年份:2006
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负责人:Prof David Jans
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依托单位:
Engineered histones as DNA carriers with application in therapeutic gene delivery
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批准号:nhmrc : 284205
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项目类别:NHMRC Project Grants
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资助金额:$27.86万
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财政年份:2004
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负责人:Prof David Jans
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依托单位:
国内基金
海外基金
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