Novel microtubule association sequences from rabies virus; subversion of antiviral responses and use in drug delivery
Novel microtubule association sequences from rabies virus; subversion of antiviral responses and use in drug delivery
批准号:
nhmrc : 545838
负责人:
Prof David Jans
金额:
$35.32万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2009
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2009-01-01 至 2011-12-31
中文摘要
点击翻译按钮获取中文摘要
英文摘要
The P-protein from rabies virus (RV) has distinct sequences that enable it to exploit the cellular skeleton (cytoskeleton) to localise efficiently in the host cell nucleus to exert pathogenic effects, or to perturb the cytoskeleton and thereby impair the host cell anti-viral response and immune response generally. We aim to characterise these properties in detail, demonstrate their importance to RV pathogenicity, and test the utility of the P-protein sequences in drug delivery.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Nuclear transport in stress
-
批准号:DP190101966
-
项目类别:Discovery Projects
-
资助金额:$37.21万
-
财政年份:2019
-
负责人:Prof David Jans
-
依托单位:
Nuclear Transport in Health and Disease; Towards Therapeutics
-
批准号:nhmrc : GNT1103050
-
项目类别:Research Fellowships
-
资助金额:$85.2万
-
财政年份:2016
-
负责人:Prof David Jans
-
依托单位:
Epigenetic regulation by PKC-theta in human breast cancer stem cells.
-
批准号:nhmrc : GNT1105409
-
项目类别:Project Grants
-
资助金额:$81.81万
-
财政年份:2016
-
负责人:Prof David Jans
-
依托单位:
Nuclear Transport in Health and Disease; Towards Therapeutics
-
批准号:nhmrc : 1103050
-
项目类别:Research Fellowships
-
资助金额:$58.74万
-
财政年份:2016
-
负责人:Prof David Jans
-
依托单位:
Epigenetic regulation by PKC-theta in human breast cancer stem cells.
-
批准号:nhmrc : 1105409
-
项目类别:Project Grants
-
资助金额:$56.28万
-
财政年份:2016
-
负责人:Prof David Jans
-
依托单位:
Transcription factor nuclear residency as a driver of gene expression
-
批准号:DP130100804
-
项目类别:Discovery Projects
-
资助金额:$25.6万
-
财政年份:2013
-
负责人:Prof David Jans
-
依托单位:
Respiratory Syncytial Virus Matrix Protein-Host Protein Interactions as Targets for Therapeutics
-
批准号:nhmrc : 1043511
-
项目类别:Project Grants
-
资助金额:$45.8万
-
财政年份:2013
-
负责人:Prof David Jans
-
依托单位:
The Essential Nuclear Transporter Importin 13; key role in brain and testis
-
批准号:nhmrc : 1022206
-
项目类别:Project Grants
-
资助金额:$40.88万
-
财政年份:2012
-
负责人:Prof David Jans
-
依托单位:
Rhinovirus protease subcellular trafficking and host cell targets; relevance to asthma exacerbation and vaccine approaches
-
批准号:nhmrc : 1027312
-
项目类别:Project Grants
-
资助金额:$38.81万
-
财政年份:2012
-
负责人:Prof David Jans
-
依托单位:
Enhanced nuclear transport in transformed cells; implications for cancer treatment
-
批准号:nhmrc : 1032143
-
项目类别:Project Grants
-
资助金额:$41.92万
-
财政年份:2012
-
负责人:Prof David Jans
-
依托单位:
Regulation of nucleocytoplasmic transport; role in health and disease
-
批准号:nhmrc : 1002486
-
项目类别:Research Fellowships
-
资助金额:$54.88万
-
财政年份:2011
-
负责人:Prof David Jans
-
依托单位:
New targets for antiviral therapies
-
批准号:DP110101749
-
项目类别:Discovery Projects
-
资助金额:$29.56万
-
财政年份:2011
-
负责人:Prof David Jans
-
依托单位:
Regulation of subcellular localisation of respiratory syncytial virus M protein: implications for pathology
-
批准号:nhmrc : 606407
-
项目类别:NHMRC Project Grants
-
资助金额:$38.69万
-
财政年份:2010
-
负责人:Prof David Jans
-
依托单位:
Nuclear functions of Dengue NS5 protein: role in disease
-
批准号:nhmrc : 606409
-
项目类别:NHMRC Project Grants
-
资助金额:$49.14万
-
财政年份:2010
-
负责人:Prof David Jans
-
依托单位:
Negative regulators of nuclear import; potential links to cancer
-
批准号:nhmrc : 491055
-
项目类别:NHMRC Project Grants
-
资助金额:$33.06万
-
财政年份:2008
-
负责人:Prof David Jans
-
依托单位:
Role of nucleocytoplasmic trafficking of Matrix protein in RSV infection
-
批准号:nhmrc : 436611
-
项目类别:NHMRC Project Grants
-
资助金额:$33.01万
-
财政年份:2007
-
负责人:Prof David Jans
-
依托单位:
The tumour cell-specific nuclear targeting properties of chicken anaemia virus VP-3: potential for anti-tumour therapy
-
批准号:nhmrc : 436614
-
项目类别:NHMRC Project Grants
-
资助金额:$31.02万
-
财政年份:2007
-
负责人:Prof David Jans
-
依托单位:
Role of the microtubule network in nuclear transport: potential use in gene delivery
-
批准号:nhmrc : 384107
-
项目类别:NHMRC Project Grants
-
资助金额:$32.79万
-
财政年份:2006
-
负责人:Prof David Jans
-
依托单位:
Research Fellowship - Grant ID:384105
-
批准号:nhmrc : 384105
-
项目类别:NHMRC Research Fellowships
-
资助金额:$50.09万
-
财政年份:2006
-
负责人:Prof David Jans
-
依托单位:
Engineered histones as DNA carriers with application in therapeutic gene delivery
-
批准号:nhmrc : 284205
-
项目类别:NHMRC Project Grants
-
资助金额:$27.86万
-
财政年份:2004
-
负责人:Prof David Jans
-
依托单位:
国内基金
海外基金
登录
查看更多内容
纤毛相关激酶受RNA编辑调控的机理研究
-
批准号:32100538
-
项目类别:青年科学基金项目(C类)
-
资助金额:30.0万元
-
批准年份:2021
-
负责人:李冬冬
-
依托单位:
用于对微管动态结构实时定量分析的荧光探针
-
批准号:32070708
-
项目类别:面上项目
-
资助金额:58.0万元
-
批准年份:2020
-
负责人:谢松波
-
依托单位:
Kinesin-8调控微管动态及减数分裂I期同源染色体分离的分子机制
-
批准号:32070707
-
项目类别:面上项目
-
资助金额:58.0万元
-
批准年份:2020
-
负责人:符传孩
-
依托单位:
微管结合蛋白WDR62调节有丝分裂纺锤体极微管负端动态性的功能及机制
-
批准号:32070705
-
项目类别:面上项目
-
资助金额:58.0万元
-
批准年份:2020
-
负责人:姜恺
-
依托单位:
Fidgetin/NDEL1介导轴突微管骨架重构的机制与轴突再生研究
-
批准号:32070725
-
项目类别:面上项目
-
资助金额:58.0万元
-
批准年份:2020
-
负责人:刘梅
-
依托单位:
圆柱瘤蛋白(CYLD)对心肌功能的调控及机制研究
-
批准号:32070787
-
项目类别:面上项目
-
资助金额:58.0万元
-
批准年份:2020
-
负责人:李登文
-
依托单位:
ENKD1在纺锤体定向中的作用及分子机制
-
批准号:32000490
-
项目类别:青年科学基金项目
-
资助金额:24.0万元
-
批准年份:2020
-
负责人:孙爽
-
依托单位:
果蝇纤毛细胞中特化细胞骨架的结构及其建立的分子基础解析
-
批准号:32070704
-
项目类别:面上项目
-
资助金额:58.0万元
-
批准年份:2020
-
负责人:梁鑫
-
依托单位:
Wdr47蛋白在神经元极化中的功能及作用机理的研究
-
批准号:31900503
-
项目类别:青年科学基金项目
-
资助金额:26.0万元
-
批准年份:2019
-
负责人:郑建群
-
依托单位:
蛋白质激酶MAPK7参与纤毛组装的功能和分子机理
-
批准号:31972888
-
项目类别:面上项目
-
资助金额:58.0万元
-
批准年份:2019
-
负责人:潘俊敏
-
依托单位: