Enhanced nuclear transport in transformed cells; implications for cancer treatment

增强转化细胞的核运输；

• 批准号: nhmrc : 1032143
• 负责人: Prof David Jans
• 金额: $ 41.92万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/enhanced-nuclear-transport-cancer-treatment/110842
• 关键词: Enhanced; nuclear; transport; transformed; cells

We have found that cancer cells are different to normal cells in terms of their ability to accumulate molecules in the cell nucleus. We intend to pursue this observation in detail, to understand the mechanism thereof, and the extent to which all types of cancer cells are similar in this regard. The results will have high relevance to understanding of oncogenesis, and of utility in approaches to anti-cancer therapies relying on the delivery of nuclear acting drugs.

我们发现癌细胞在细胞核中积累分子的能力与正常细胞不同。我们打算详细研究这一观察结果，以了解其机制，以及所有类型的癌细胞在这方面的相似程度。这些结果将与了解肿瘤发生以及依赖于核作用药物递送的抗癌疗法方法的实用性具有高度相关性。