Enhanced nuclear transport in transformed cells; implications for cancer treatment
Enhanced nuclear transport in transformed cells; implications for cancer treatment
批准号:
nhmrc : 1032143
负责人:
Prof David Jans
金额:
$41.92万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2012
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2012-01-01 至 2015-12-31
中文摘要
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英文摘要
We have found that cancer cells are different to normal cells in terms of their ability to accumulate molecules in the cell nucleus. We intend to pursue this observation in detail, to understand the mechanism thereof, and the extent to which all types of cancer cells are similar in this regard. The results will have high relevance to understanding of oncogenesis, and of utility in approaches to anti-cancer therapies relying on the delivery of nuclear acting drugs.
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Epigenetic regulation by PKC-theta in human breast cancer stem cells.
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Transcription factor nuclear residency as a driver of gene expression
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Respiratory Syncytial Virus Matrix Protein-Host Protein Interactions as Targets for Therapeutics
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The Essential Nuclear Transporter Importin 13; key role in brain and testis
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Regulation of nucleocytoplasmic transport; role in health and disease
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New targets for antiviral therapies
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Regulation of subcellular localisation of respiratory syncytial virus M protein: implications for pathology
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Nuclear functions of Dengue NS5 protein: role in disease
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Novel microtubule association sequences from rabies virus; subversion of antiviral responses and use in drug delivery
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依托单位:
Negative regulators of nuclear import; potential links to cancer
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批准号:nhmrc : 491055
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项目类别:NHMRC Project Grants
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资助金额:$33.06万
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财政年份:2008
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负责人:Prof David Jans
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依托单位:
Role of nucleocytoplasmic trafficking of Matrix protein in RSV infection
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批准号:nhmrc : 436611
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项目类别:NHMRC Project Grants
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资助金额:$33.01万
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财政年份:2007
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依托单位:
The tumour cell-specific nuclear targeting properties of chicken anaemia virus VP-3: potential for anti-tumour therapy
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批准号:nhmrc : 436614
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项目类别:NHMRC Project Grants
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资助金额:$31.02万
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财政年份:2007
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依托单位:
Role of the microtubule network in nuclear transport: potential use in gene delivery
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批准号:nhmrc : 384107
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项目类别:NHMRC Project Grants
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资助金额:$32.79万
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财政年份:2006
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负责人:Prof David Jans
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依托单位:
Research Fellowship - Grant ID:384105
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批准号:nhmrc : 384105
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项目类别:NHMRC Research Fellowships
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资助金额:$50.09万
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财政年份:2006
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依托单位:
Engineered histones as DNA carriers with application in therapeutic gene delivery
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项目类别:NHMRC Project Grants
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资助金额:$27.86万
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财政年份:2004
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负责人:Prof David Jans
-
依托单位:
国内基金
海外基金
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