Rhinovirus protease subcellular trafficking and host cell targets; relevance to asthma exacerbation and vaccine approaches

鼻病毒蛋白酶亚细胞运输和宿主细胞靶标；

• 批准号: nhmrc : 1027312
• 负责人: Prof David Jans
• 金额: $ 38.81万
• 依托单位: University of Canberra
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/rhinovirus-protease-subcellular-vaccine-approaches/110557
• 关键词: Rhinovirus; protease; subcellular; trafficking; host

Rhinovirus (RV) infections are the major cause of virus induced asthma attacks, causing significant morbidity and mortality. Asthma & asthma exacerbations are increasing worldwide with new strategies urgently needed to reduce RV-associated disease. We aim to build on our substantive new data, using cutting edge technology to identify new targets for novel asthma therapies.

鼻病毒（RV）感染是病毒诱导的哮喘发作的主要原因，导致显著的发病率和死亡率。哮喘和哮喘急性发作在全球范围内不断增加，迫切需要新的策略来减少RV相关疾病。我们的目标是在大量新数据的基础上，利用尖端技术确定新型哮喘治疗的新靶点。