Regulation of nucleocytoplasmic transport; role in health and disease

核细胞质运输的调节；

• 批准号: nhmrc : 1002486
• 负责人: Prof David Jans
• 金额: $ 54.88万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-nucleocytoplasmic-transport-health-disease/108818
• 关键词: Regulation; nucleocytoplasmic; transport; role; health

Transport into and out of the nucleus is central to the function of the cells from complex organisms such as mammals. This research program aims to improve understanding of nuclear transport and its regulation in the context of infection by medically relevant viruses, as well as in the context of cancer, and normal cell growth/development. It will contribute to developing new anti-viral therapeutics/vaccines, drug delivery strategies for cancer, and understanding causes of male infertility.

进出细胞核的运输是复杂生物体（如哺乳动物）细胞功能的核心。本研究计划旨在提高对核转运及其在医学相关病毒感染、癌症和正常细胞生长/发育背景下的调控的理解。它将有助于开发新的抗病毒疗法/疫苗、癌症药物递送策略以及了解男性不育的原因。