SITE SPECIFIC CHARACTERIZATION OF LACCASE GLYCANS FROM WHITE ROT FUNGUS

白腐真菌漆酶聚糖的位点特异性表征

• 批准号: 6653545
• 负责人: RON ORLANDO
• 金额: $ 28.8万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6653545
• 关键词: Mammalia; biomedical resource; carbohydrates; enzymes; gene therapy; genetically modified animals; genetics; nervous system; technology /technique

We are collaborating on the generation of a mouse gene knockout for the lysosomal ?-mannosidase as an animal model for the human genetic disease ?-mannosidosis. Gene disruption constructs prepared in the Moremen laboratory are being used by Dr. Condie to generate the knockout mice. The homozygous null mice will be analyzed in the Moremen laboratory for the storage phenotype and potentially used as a model for the testing of therapeutic strategies.

我们正在合作鼠标基因敲除 对于溶酶体？ - 甘露糖苷酶作为人类的动物模型 遗传疾病？ - 甘露术。 制备的基因破坏构建体 康迪博士在莫里曼的实验室中使用 淘汰老鼠。 将在 储存表型的莫曼人实验室，并有可能用作 测试治疗策略的模型。