Neurophysiologic, Performance And Subjective Effects Of

神经生理学、表现和主观影响

• 批准号: 6830555
• 负责人: Wallace Bruce Pickworth
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON DRUG ABUSE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6830555
• 关键词: attention; behavioral /social science research tag; behavioral genetics; clinical research; drug addiction; drug withdrawal; electroencephalography; human subject; neuropharmacology; nicotine; performance; psychopharmacology; smokeless tobacco; smoking; tobacco; tobacco abuse

Several clinical studies are performed to determine objective and subjective measures associated with smoking and tobacco withdrawal. The results of these studies are applied to develop paradigms for testing of drugs for the treatment of nicotine withdrawal. Neurophysiologic data indicate that nicotine acts on neural substrates involved in attention, cognition and memory. For example, the effects of mecamylamine, a centrally acting nicotinic antagonist is studied to determine the contribution of tonic cholinergic mechanisms on the EEG and cognitive tasks in smokers and nonsmokers. Studies on the effects of smokeless tobacco products, and a newly developed denicotinized cigarette are completed. In an ongoing project, the effects of cigarettes that do not deliver nicotine were compared to placebo cigarettes in a spaced-smoking paradigm. In another study, the effects of the denicotinized cigarettes in a rapid smoking procedure are evaluated. Genetic mechanisms involved in the effect and appeal of cigarette smoking and tobacco withdrawal are investigated. These studies contribute to an understanding of the mechanisms of nicotine addiction and are also of practical value in the development of more effective medications for treating nicotine dependence and withdrawal. Proposed studies include estimating the role of the Nurr1 gene in cigarette smoking behavior. Further studies with alternative tobacco and nicotine delivery products such as hookah smoking are in development. Also being developed is a new test for tobacco exposure by measures of salinisol in cigarette butts.

进行了几项临床研究，以确定与吸烟和烟草戒断相关的客观和主观指标。这些研究的结果应用于开发用于治疗尼古丁戒断的药物的测试范例。神经生理学数据表明，尼古丁作用于参与注意力、认知和记忆的神经基质。例如，研究了中枢作用烟碱拮抗剂美加明的作用，以确定强直性胆碱能机制对吸烟者和非吸烟者的EEG和认知任务的贡献。对无烟烟草制品的作用进行了研究，并研制了一种新型的脱尼古丁卷烟。在一个正在进行的项目中，不提供尼古丁的香烟的效果在空间吸烟范例中与安慰剂香烟进行了比较。在另一项研究中，评估了脱尼古丁香烟在快速吸烟过程中的作用。研究了吸烟和戒烟的影响和吸引力所涉及的遗传机制。这些研究有助于了解尼古丁成瘾的机制，也对开发更有效的治疗尼古丁依赖和戒断的药物具有实用价值。拟议的研究包括估计Nurr1基因在吸烟行为中的作用。目前正在进一步研究替代烟草和尼古丁输送产品，如水烟。同时正在开发一种新的测试烟草暴露的方法，即测量烟头中的盐。