NIEHS Statistical Consulting Service

统计咨询处(SCS)于1996年正式成立，在设计、分析和解释研究所研究活动的实验结果方面提供统计和计算方面的专门知识。统计司提供的统计专门知识范围从关于数据分析的建议到更广泛的合作研究努力，从而在专题期刊上联合发表文章。这些咨询项目涉及各种科学努力，包括实验室和人体研究。生物统计处的一些统计员在不同程度上参与了统计司的工作。这份资源审查报告概述了上述生物统计科统计员为实验室研究项目提供的咨询/合作。在2004财年，超过75名科学家使用了SCS。其中一些活动涉及国家毒理学计划(NTP)的长期啮齿动物致癌性研究。在2004财政年度期间，我们为编写15份NTP技术报告和7份正在编写中的其他报告提供了大量投入。 其他已发表合作的例子包括 (I)出生后宫内暴露齐多夫定和拉尼夫定对小鼠的影响 小鼠心肌细胞线粒体损伤的实验研究。 (Ii)研究PGE_2受体和cAMP-PKA在IL-1a诱导的人呼吸道上皮细胞粘蛋白产生中的作用。 (Iii)评估硫芥末对环氧合酶-2基因敲除小鼠和塞来昔布治疗小鼠的皮肤毒性。 (Iv)对化学诱导的人溶血性疾病与血栓形成相关的大鼠模型--一种新的骨缺血性坏死模型--的骨坏死进行评估。 (V)2，3，7，8-四氯二苯并-对-二恶英和二恶英类化合物慢性处理后雌性Harlan Spraogue-Dawley大鼠胰腺外分泌病理的研究。

The Statistical Consulting Service (SCS) was formally established in 1996 to provide statistical and computational expertise in the design, analysis, and interpretation of experimental results from Institute research activities. Statistical expertise provided by the SCS ranges from advice regarding data analysis to more extensive collaborative research efforts that result in joint publications in subject matter journals. These consulting projects involve a variety of scientific endeavors, including both laboratory and human studies. A number of statisticians from the Biostatistics Branch are involved in varying degrees with the SCS. This Resource Review report summarizes the consulting/collaborations provided by theBiostatistics Branch statisticians identified above for projects dealing with laboratory research. Over 75 scientists made use of the SCS in FY2004. Some of these activities involved the National Toxicology Program's (NTP's) long term rodent carcinogenicity studies. During FY2004 we provided significant input into the preparation of 15 NTP Technical Reports and 7 others which are in preparation. Examples of other published collaborations include (i) a study of the effect of in utero postnatal exposure Zidovudine and Larnivudine on the mitochondrial damage of mouse pup cardiomyocytes. (ii) a study of the effect of PGE2 receptors and cAMP-PKA on IL-1a induced mucin production in human airway epithelium. (iii) an evaluation of sulfur mustard-induced skin toxicity in cyclooxygenase-2 knockout and celecoxib-treated mice. (iv) an evaluation of Osteonecrosis in a chemically induced rat model of human hemolytic disorders associated with thrombosis - A new model for avascular necrosis of bone. (v) a study of exocrine pancreatic pathology in female Harlan Sprague-Dawley rats after chronic treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin and dioxin-like compounds.