NIEHS Statistical Consulting Service

NIEHS统计咨询服务

• 批准号: 7007166
• 负责人: SHYAMAL PEDDADA
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7007166
• 关键词: brca gene; carcinogens; computer data analysis; data management; dioxins; hepatotoxin; laboratory mouse; leiomyoma; liver neoplasms; neoplasm /cancer epidemiology; oxidative stress; p53 gene /protein; prostaglandin endoperoxide synthase; radiation carcinogenesis; statistical service /center; statistics /biometry; toxicology information system; ultraviolet radiation

The Statistical Consulting Service (SCS) was formally established in 1996 to provide statistical and computational expertise in the design, analysis, and interpretation of experimental results from Institute research activities. Statistical expertise provided by the SCS ranges from advice regarding data analysis to more extensive collaborative research efforts that result in joint publications in subject matter journals. These consulting projects involve a variety of scientific endeavors, including both laboratory and human studies. A number of statisticians from the Biostatistics Branch are involved in varying degrees with the SCS. This Resource Review report summarizes the consulting/collaborations provided by theBiostatistics Branch statisticians identified above for projects dealing with laboratory research. Over 75 scientists made use of the SCS in FY2004. Some of these activities involved the National Toxicology Program's (NTP's) long term rodent carcinogenicity studies. During FY2004 we provided significant input into the preparation of 15 NTP Technical Reports and 7 others which are in preparation. Examples of other published collaborations include (i) a study of the effect of in utero postnatal exposure Zidovudine and Larnivudine on the mitochondrial damage of mouse pup cardiomyocytes. (ii) a study of the effect of PGE2 receptors and cAMP-PKA on IL-1a induced mucin production in human airway epithelium. (iii) an evaluation of sulfur mustard-induced skin toxicity in cyclooxygenase-2 knockout and celecoxib-treated mice. (iv) an evaluation of Osteonecrosis in a chemically induced rat model of human hemolytic disorders associated with thrombosis - A new model for avascular necrosis of bone. (v) a study of exocrine pancreatic pathology in female Harlan Sprague-Dawley rats after chronic treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin and dioxin-like compounds.

统计咨询服务（SCS）于1996年正式成立，旨在为研究所研究活动的实验结果的设计，分析和解释提供统计和计算专业知识。SCS提供的统计专业知识包括有关数据分析的建议，以及更广泛的合作研究工作，这些工作导致在主题期刊上联合发表文章。这些咨询项目涉及各种科学工作，包括实验室和人体研究。来自生物统计分支的一些统计学家在不同程度上参与了SCS。本资源审查报告总结了上述生物统计分支统计学家为实验室研究项目提供的咨询/合作。在2004财政年度，超过75名科学家使用了SCS。其中一些活动涉及国家毒理学计划（NTP）的长期啮齿动物致癌性研究。在2004财政年度，我们为15份NTP技术报告和7份正在编写的其他报告的编写提供了重要投入。 其他已发表的合作案例包括 (i)宫内暴露齐多夫定和拉尼夫定对胎儿生长发育影响的研究 小鼠幼仔心肌细胞的线粒体损伤。 (ii)PGE 2受体和cAMP-PKA对IL-1 α诱导的人气道上皮粘蛋白产生的影响的研究。 (iii)硫芥诱导的环氧合酶-2敲除和塞来昔布治疗小鼠皮肤毒性的评价。 (iv)在与血栓形成相关的人类溶血性疾病的化学诱导大鼠模型中评价骨坏死-骨缺血性坏死的新模型。 (v)雌性哈兰Sprague-Dawley大鼠长期接受2，3，7，8-四氯二苯并-p-二恶英和二恶英样化合物治疗后胰腺外分泌病理学的研究。