NIEHS Statistical Consulting Service

NIEHS统计咨询服务

• 批准号: 7593900
• 负责人: SHYAMAL PEDDADA
• 金额: $ 38.49万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7593900
• 关键词: Acute Lymphocytic Leukemia; Biometry; Birth Weight; Body mass index; CD34 gene; Caffeine; Cardiotoxicity; Child; Cholesterol Homeostasis; Collaborations; Consult; Data; Data Analyses; Development; Ephedra sinica; Ephedrine; Epidemiologic Studies; Genes; Genetic Variation; Gestational Age; Hair follicle structure; Human; Joints; Journals; Laboratories; Manuscripts; Mothers; Numbers; Ozone; Play; Pregnancy Maintenance; Premature Birth; Premature Infant; Premature Labor; Preparation; Progesterone; Progesterone Receptors; Publications; Range; Rattus; Receptor Gene; Recurrence; Research; Research Personnel; Risk; Role; Scientist; Services; Skin Neoplasms; Stem cells; Variant; design; fetal; genetic variant; human study; prevent; pulmonary function

The biostatisticians participating in the statistical consulting service co-authored about 40 research publications in collaboration with scientists within DIR and outisde the DIR. There are several more manuscripts that are under preparation. Some examples of research findings include; - Progesterone plays a critical role in the maintenance of pregnancy and has been effectively used to prevent recurrences of preterm labor. We investigated the role of genetic variation in the progesterone receptor (PGR) gene in modulating risks for preterm labor by examining both maternal or fetal effects. We identified significant associations between SNPs in the PGR for both mother and preterm infant. - Examined the contribution of variants in fetal and maternal cholesterol metabolism genes in preterm delivery (PTD). We found that variants in maternal and fetal genes for cholesterol metabolism were associated with PTD and decreased birth weight or gestational age. - Identified a genetic variant associated with acute lymphoblastic leukemia in children. - Investigated the effects of ozone and body mass index on pulmonary function. - Investigated the cardiotoxicity of ma huang and ephedrine, with and without caffeine, in rats. - Investigated the skin tumor development following CD34 expression in hair follicle stem cells.

参与统计咨询服务的生物统计学家与联合国内外的科学家合作，共同撰写了约40份研究出版物。还有几份手稿正在编写中。 研究结果的一些例子包括： - 孕激素在维持妊娠中起着关键作用，并已被有效地用于预防早产的复发。我们通过检查母体或胎儿的影响，研究孕激素受体（PGR）基因的遗传变异在调节早产风险中的作用。我们确定了母亲和早产儿PGR中SNPs之间的显著关联。 - 检查胎儿和母体胆固醇代谢基因变异在早产（PTD）中的作用。我们发现母体和胎儿胆固醇代谢基因的变异与PTD和出生体重或胎龄降低有关。 - 确定了一种与儿童急性淋巴细胞白血病相关的遗传变异。 - 探讨了臭氧和体重指数对肺功能的影响。 - 研究了麻黄和麻黄素与咖啡因合用和不合用对大鼠心脏的毒性。 - 研究了毛囊干细胞表达CD34后皮肤肿瘤的发展。