NIEHS Statistical Consulting Service

参与统计咨询服务的生物统计学家与DIR和OUTISDE DIR的科学家合作，共同撰写了约40份研究出版物。还有几份手稿正在准备中。研究结果的一些例子包括； -黄体酮在维持妊娠方面发挥关键作用，并已被有效地用于防止早产复发。我们通过检测母体或胎儿的影响，研究了孕激素受体(PGR)基因的遗传变异在调节早产风险中的作用。我们发现PGR中的SNPs与母亲和早产儿之间存在显著的相关性。 -研究了胎儿和母亲胆固醇代谢基因变异在早产(PTD)中的作用。我们发现，母体和胎儿胆固醇代谢基因的变异与PTD和出生体重或胎龄降低有关。 -发现了一种与儿童急性淋巴细胞性白血病有关的基因变异。 -调查臭氧和体重指数对肺功能的影响。 -研究麻黄和麻黄素在加和不加咖啡因的情况下对大鼠的心脏毒性。 -研究了毛囊干细胞表达CD34后皮肤肿瘤的发展。

The biostatisticians participating in the statistical consulting service co-authored about 40 research publications in collaboration with scientists within DIR and outisde the DIR. There are several more manuscripts that are under preparation. Some examples of research findings include; - Progesterone plays a critical role in the maintenance of pregnancy and has been effectively used to prevent recurrences of preterm labor. We investigated the role of genetic variation in the progesterone receptor (PGR) gene in modulating risks for preterm labor by examining both maternal or fetal effects. We identified significant associations between SNPs in the PGR for both mother and preterm infant. - Examined the contribution of variants in fetal and maternal cholesterol metabolism genes in preterm delivery (PTD). We found that variants in maternal and fetal genes for cholesterol metabolism were associated with PTD and decreased birth weight or gestational age. - Identified a genetic variant associated with acute lymphoblastic leukemia in children. - Investigated the effects of ozone and body mass index on pulmonary function. - Investigated the cardiotoxicity of ma huang and ephedrine, with and without caffeine, in rats. - Investigated the skin tumor development following CD34 expression in hair follicle stem cells.