Order Restricted Inference With Applications To Toxicolo

订购限制推理与 Toxicolo 的应用程序

• 批准号: 6673289
• 负责人: SHYAMAL PEDDADA
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6673289
• 关键词: data collection methodology /evaluation; dosage; epidemiology; human mortality; method development; neoplastic growth; statistics /biometry; toxicology

This project focuses on developing new statistical methods, and applying new and existing statistical techniques, to analyze order-restricted toxicology data. One area of research focused on tests for dose-related trends in tumor rates. A general procedure was developed which can be applied to a wide array of problems, including some of those encountered in National Toxicology Program (NTP) studies. This new test is more powerful than the current (Poly-3) test and is robust with respect to the shape of the dose-response curve, the effects of dose on mortality, the spacings between doses, and the size of the background tumor rate. Similar techniques were developed to more efficiently estimate confidence intervals and to detect trends when the data are correlated. Also, new methods were developed to analyze data from heterogeneous sources (e.g. different laboratories).

这个项目的重点是开发新的统计方法，并应用新的和现有的统计技术来分析顺序受限的毒理学数据。其中一个研究领域专注于测试肿瘤发病率中与剂量相关的趋势。开发了一种通用程序，可应用于各种问题，包括国家毒理学计划(NTP)研究中遇到的一些问题。这种新的测试比目前的(Poly-3)测试更强大，在剂量-反应曲线的形状、剂量对死亡率的影响、剂量之间的间隔以及背景肿瘤率的大小方面都是可靠的。开发了类似的技术，以更有效地估计可信区间，并在数据相关时检测趋势。此外，还开发了新的方法来分析来自不同来源(例如不同的实验室)的数据。

项目成果

Tests for order restrictions in binary data.

测试二进制数据中的顺序限制。

• DOI: 10.1111/j.0006-341x.2001.01219.x
• 发表时间: 2001
• 期刊: Biometrics
• 影响因子: 1.9
• 作者: Peddada,SD;Prescott,KE;Conaway,M
• 通讯作者: Conaway,M