BABOON IMMUNE RESPONSES TO NP-ISS + INFLUENZA VACCINE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本实验的目的是确定NP-1018和NP-C295与商业流感疫苗混合是否能提高狒狒对含血凝素抗原（HA）的流感疫苗的免疫反应。本研究将在狒狒中测试两种新的配方（NP-1018和NP- c295），该配方由免疫刺激DNA序列（ISS）结合流感病毒重组核蛋白（NP）组成。试验共设6组，每组5只

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this experiment is determine if mixing NP-1018 and NP-C295 with commercial influenza vaccine improves the immune responses of baboons to influenza vaccine, consisting of hemaglutinnin antigen (HA). This study in baboons will test two new formulations (NP-1018 and NP-C295) consisting of immunostimulatory DNA sequences (ISS) conjugated to recombinant nuclear protein (NP) of influenza virus. This study will consist of 6 groups of 5 animals per group