EFFECT OF CLA SUPPLEMENTS ON BODY WEIGHT AND FAT OXIDATION

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本研究已关闭。 自1970年以来，美国肥胖成年人的数量大幅增加。目前，美国超过60%的成年人超重或肥胖。然而，通过饮食和运动来减轻体重的肥胖症治疗只有适度的效果，因为大多数人往往会在治疗后五年内重新获得他们可能失去的体重。因此，我们研究了一种已知可以减少动物肥胖的安全膳食补充剂的效果。我们在人类受试者中进行了一项为期六个月的对照临床试验，以确定共轭亚油酸（CLA）在减肥和脂肪燃烧方面的功效。一半的受试者每天补充CLA和一半的非活性油，无论是运行研究的人还是参与者都不知道他们是否接受CLA或非活性油。49名健康超重的成年人接受了研究。他们被建议采取健康的生活方式，包括轻度到中度的体力活动，减少膳食脂肪和增加膳食纤维的摄入。在超重的成年人中补充六个月的CLA使身体脂肪减少了3.7磅，而在节日期间食用非活性油的受试者增加了2磅。这表明CLA可能在减少成年期累积的体重和脂肪增加方面发挥作用，特别是在许多人体重增加的节日期间。与不活跃的油相比，CLA治疗增加了睡眠期间的脂肪燃烧。增加表明CLA通过增加一个人燃烧多少脂肪来起作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is closed. There has been a large increase in the number of obese adults in the United States since 1970. Currently, over 60% of adults in the U.S. are overweight or obese. Treatment of obesity by diet and exercise to reduce body weight, however, has only been moderately effective as most individuals tend to regain any weight they may have lost within five years after treatment. We therefore investigated the effects of a safe dietary supplement that is known to reduce obesity in animals. We performed a controlled six-month clinical trial in human subjects to determine the efficacy of conjugated linoleic acid (CLA) in fat loss and fat burned. Half of the subjects received daily supplements of CLA and half an inactive oil in a way in which neither the people running the study nor the participants know if they are receiving CLA or the inactive oil. Forty-nine healthy, overweight adults were studied. They were counseled on a healthy lifestyle including mild to moderate physical activity, decreased dietary fat and increased dietary fiber consumption. Six months of CLA supplementation among overweight adults reduced body fat by 3.7 lbs while the subjects eating the inactive oil gained 2 lbs during the holiday season. This indicates that CLA may play a role in lessening the cumulative weight and fat gains that occur during adulthood, particularly during the holiday season when many people gain weight. The CLA treatment increased fat burning during sleep compared to the inactive oil. The increase indicates that CLA acts by increasing how much fat a person burns.