NATIONAL NEUROLOGICAL AIDS BANK

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。国家神经艾滋病银行（NNAB）的主要目标是为晚期艾滋病患者和其他疾病的血清阴性对照患者提供特征明确的人体组织、体液和医疗数据。招募受试者并对其终生进行纵向跟踪，进行标准化和质量控制的检查，包括每6个月进行一次神经医学检查、神经心理学测试、精神病学/药物滥用/毒理学测试、血液、尿液和脑脊液采集。采用一种算法方法来实现基于AAN标准的一系列神经医学诊断。实验对象在死前同意在死后进行快速尸检。遵循标准化的神经病理学协议来切割，准备和储存组织，并建立一系列标准化的神经病理学诊断。系统组织的制备方法类似。死后液体、福尔马林固定和冷冻组织免费提供给合格的研究人员（除了运输），他们向我们的指导委员会提交审查方案。虽然不是原始RFA的一部分，但NNAB已经在原始方案的基础上，在丙型肝炎合并感染、临床研究和神经影像学领域建立了几个附加方案，我们期待充分利用这一队列。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The major goal of this R24 grant, National Neurological AIDS Bank (NNAB), is to provide well-characterized human tissue, fluids, and medical data from subjects with advanced AIDS and seronegative comparison subjects with other diseases. Subjects are recruited and followed longitudinally during life, with standardized and quality-controlled examinations that include a neuromedical examination, neuropsychological testing, psychiatric/substance abuse/toxicological testing, blood, urine, and CSF collection every 6 months. An algorthymic approach is followed to achive a series of neuromedical diagnoses based on the AAN criteria. Subjects give pre-mortem consent to a rapid autopsy after death. A standardized neuropathological protocol is followed to cut, prepare, and store tissue, and to establish a series of standardized neuropathological diagnoses. Systemic tissue is prepared similarly. Post-mortem fluids, formalin-fixed, and frozen tissue is available at no cost (except for shipping) to qualified researchers who submit protocols for review to our Steering Committee. Although not a part of the original RFA, NNAB has established several add-on protocols in the area of Hepatitis C co-infection, clinical studies, and neuroimaging to the original protocol, and we look forward to taking full advantage of this cohort.