National Neurological AIDS Bank

描述（由申请人提供）：本申请代表加州大学洛杉矶分校国家神经系统艾滋病银行（NNAB）的更新，为额外5年的资金，以开展银行的资源和研究活动。自1998年以来，NNAB为研究神经艾滋病的病因和治疗提供了人体组织、体液和数据。NNAB招募了一个种族，民族和语言多样化的群体，独特的和代表大洛杉矶，加利福尼亚州地区。我们成功地对患有以下疾病的人进行了纵向研究 晚期艾滋病和艾滋病毒血清阴性对照。这些受试者同意接受一系列临床检查，在其生命期间捐献其血液、尿液和脑脊液，并在其死亡后捐献其组织和器官。一组受试者还接受单独资助的纵向磁共振成像/磁共振波谱扫描，为队列增加了进一步的科学价值。从2002年到2007年年中，我们向全世界的艾滋病研究人员提出了68项独特的组织和体液请求。NNAB还收集有关在神经和精神疾病的发病机制中与HIV相互作用的共病条件的信息，并研究检测HIV+少数受试者认知障碍的最佳方法。在这里，我们描述了我们的新研究议程。我们率先制定了NNTC共病研究计划，通过增加有关衰老、肝炎、代谢和心血管疾病、烟草使用、依从性、非艾滋病毒药物使用的数据，以及丰富所收集的药物滥用数据，增加NNTC样本的价值。我们招募了2名新成员加入科学领导小组，他们提供流行病学和神经艾滋病临床研究方面的专业知识。我们已经开展了研究，以更好地诊断我们的多样化队列中的神经认知障碍，寻找艾滋病相关神经和精神疾病的宿主遗传标记，我们增加了与研究神经病毒学，遗传学，HIV药物毒性和药物滥用的研究人员的合作。NNAB为科学界和神经艾滋病患者提供了宝贵的资源和研究资产。NNAB的研究招募并检查了患有艾滋病和其他疾病的捐赠者。志愿者同意在生前捐献医疗信息和体液样本，死后捐献组织和器官。这些组织被分发给有价值的科学家，用于医学研究。NNAB还对与HIV感染相关的神经系统疾病的诊断，原因和治疗进行了自己的研究，如HIV痴呆，脊髓病，周围神经病，肌病，精神疾病和HIV患者的药物毒性。 A部分：

DESCRIPTION (provided by applicant): This application represents the renewal of the UCLA National Neurological AIDS Bank (NNAB) for an additional 5 years of funding to carry out the resource and research activities of the Bank. Since 1998, NNAB has provided human tissues, fluids, and data for research into the causes and treatment of Neuro-AIDS. NNAB has recruited a racially, ethnically, and linguistically diverse cohort distinctive to and representative of the greater Los Angeles, CA area. We have successfully conducted a longitudinal study of persons with advanced AIDS and HIV-seronegative controls. These subjects have agreed to undergo serial clinical examinations, to donate their blood, urine, and cerebrospinal fluid during their lives, and to donate their tissues and organs after their deaths. A group of subjects also receives separately funded longitudinal magnetic resonance imaging/magnetic resonance spectroscopy scans that add further scientific value to the cohort. Between 2002 and mid-2007 we filled 68 unique requests comprised of tissue and fluids to AIDS researchers worldwide. NNAB also collects information about co-morbid conditions that interact with HIV in the pathogenesis of neurological and psychiatric disorders, and investigates the best methods to detect cognitive impairment in our HIV+ minority subjects. Herein, we describe our new research agenda. We have taken the lead in plans for NNTC co-morbidity research, that will increase the value of the NNTC samples by adding data on aging, hepatitis, metabolic and cardiovascular disorders, tobacco use, adherence, use of non-HIV medications, and by enriching the substance abuse data collected. We have recruited 2 new members to the Scientific Leadership Group who offer expertise in epidemiology and Neuro-AIDS clinical studies. We have developed studies to better diagnose neurocognitive disorders in our diverse cohort, to search for host-genetic markers of AIDS-related neurological and psychiatric disorders, and we have increased our collaborations with investigators who study neurovirology, genetics, toxicity of HIV drugs, and substance abuse. NNAB offers an invaluable resource and research asset to the scientific community and to people afflicted by Neuro-AIDS. Lay Language Summary: The NNAB study recruits and examines donors with AIDS and other diseases. Volunteers agree to donate medical information and samples of their body fluids during their lives, and their tissues and organs after their deaths. This tissue is distributed to worthy scientists for the purpose of medical research. NNAB also conducts its own research into the diagnosis, causes, and cures for neurological diseases associated with HIV infection, such as HIV dementia, myelopathy, peripheral neuropathy, myopathy, psychiatric disorders, and medication toxicity in HIV patients. Part A: