NATIONAL NEUROLOGICAL AIDS BANK

描述（由申请人提供）：这一竞争性更新申请旨在继续计算解剖学和多维建模资源，旨在超越当前假定静态形态学并禁止检查时变变化的脑地图集和地图。申请人建议继续开发框架和工具，以严格评估大脑结构和功能的动态变化，特别关注诸如发育，衰老和特定疾病的进展等过程。四个研究领域被认为是至关重要的：表面参数化、体积参数化、特征提取、集成和可视化。其中每一个都是为了补充其他的，形成一个综合和全面的研究计划。这个专注于计算解剖学和多维建模的中心与许多其他专注于图像采集的神经成像中心形成鲜明对比。该资源下的努力包括与一个多样化和资金充足的基础、应用和临床科学家小组进行大量合作，研究健康和疾病中的神经科学问题。这些项目是根据其与核心研究计划和资助项目的具体目标的互利共生关系选择的。该资源将继续以强大的软件、访问其计算机硬件资源以及制作动画和图像渲染的形式为其他调查人员提供服务。关于资源的信息将通过出版物、电子媒体和小册子传播，并制作描述资源、其软件、专门知识、培训和合作机会的迷你cd。为学生和同事提供现场和远程培训机会，包括实践经验，准备材料，研讨会和交互式电子演示。行政结构包括

DESCRIPTION (Provided by Applicant): This competitive renewal application to continue a Resource for computational anatomy and multidimensional modeling is intended go beyond current atlases and maps of the brain that assume a static morphology and prohibit the examination of time-varying changes. The applicants propose to continue to develop the framework and tools to rigorously evaluate dynamic changes in brain structure and function, focusing particularly on processes such as development, aging and the progression of specific diseases. Four areas of research are identified as being of critical importance: Surface Parameterization, Volume Parameterization, Feature Extraction, and Integration and Visualization. Each of these is intended to complement the others to form an integrated and comprehensive research program. This focus on computational anatomy and multidimensional modeling is in contrast to many other neuroimaging centers where the focus is on image acquisition. Efforts under this Resource include numerous collaborations with a diverse and well-funded group of basic, applied and clinical scientists working on neuroscientific problems in health and disease. These projects were selected on the basis of their mutually beneficial, symbiotic relationship with the core research plans and the specific aims of their funded projects. The Resource will continue to provide service to other investigators in the form of robust software, access to its computer hardware resources and production of animations and image renderings. Information about the Resource will be disseminated by publication, electronic media and a brochure, and the creation of mini-CD's describing the Resource, its software, expertise, training and collaborative opportunities. Training opportunities for students and colleagues are available on site and remotely and include hands-on experiences, prepared material, workshops, and interactive electronic presentations. An administrative structure consist