NATIONAL NEUROLOGICAL AIDS BANK (NNAB)

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 具体目标 1. NNAB将继续发展其网络，应用NNTC批准的和当地的NNAB协议来描述艾滋病毒感染者和艾滋病毒血清阴性对照受试者的特征。 NNAB将采集特征良好的组织、血液、脑脊液和尿液，并将这些组织和液体分发给合格的研究者。 NNAB将开发其捐赠计划、基础设施、数据库和独立研究项目。 NNAB将通过宣传该银行和与其他调查人员合作，促进其资源的利用。 a. NNAB将继续强调纳入种族，民族和语言多样性的主题，重点是招募，保留和描述历史上在组织库和研究中代表性不足的群体成员。 这将有助于满足对来自美国和其他地方艾滋病患者的人口统计学和遗传学代表性受试者的医学信息和临床标本的需求。 B. NNAB将收集重要的信息，以研究关键的共病医疗条件的影响，如丙型肝炎病毒（HCV）合并感染，高血压，糖尿病，血脂紊乱，以及其他与HIV及其治疗相关的代谢异常，对我们样本中HIV相关神经系统疾病的发展。 C. NNAB将开发一个选择性招募的具有良好特征的HIV对照受试者队列，以补充我们的HIV+样本，并为研究提供比较组织。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SPECIFIC AIMS 1. The NNAB will continue to develop its network, applying NNTC-approved and local NNAB protocols to characterize HIV-infected and HIV-seronegative comparison subjects. NNAB will acquire well-characterized tissue, blood, cerebrospinal fluid and urine and will distribute such tissue and fluids to well-qualified investigators. NNAB will develop its donation program, infrastructure, database, and independent research projects. NNAB will promote utilization of its resources by publicizing the Bank and by forming collaborations with other investigators. a. The NNAB will continue to emphasize the inclusion of racially, ethnically, and linguistically diverse subjects, with an emphasis on recruiting, retaining, and characterizing members of groups that historically have been under-represented in tissue banks and in research studies. This will help address the need for medical information and clinical specimens from subjects that are demographically and genetically representative of AIDS patients in the United States and elsewhere. b. The NNAB will collect information essential to study the effects of key co-morbid medical conditions such as hepatitis C virus (HCV) co-infection, hypertension, diabetes, lipid disorders, and other metabolic abnormalities associated with HIV and its treatment, on the development of HIV-associated neurological disease in our sample. c. The NNAB will develop a selectively recruited cohort of well-characterized HIV- comparison subjects to complement our HIV+ sample and to provide comparison tissues for research.