NATIONAL NEUROLOGICAL AIDS BANK (NNAB)

这个子项目是众多研究子项目之一

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SPECIFIC AIMS 1. The NNAB will continue to develop its network, applying NNTC-approved and local NNAB protocols to characterize HIV-infected and HIV-seronegative comparison subjects. NNAB will acquire well-characterized tissue, blood, cerebrospinal fluid and urine and will distribute such tissue and fluids to well-qualified investigators. NNAB will develop its donation program, infrastructure, database, and independent research projects. NNAB will promote utilization of its resources by publicizing the Bank and by forming collaborations with other investigators. a. The NNAB will continue to emphasize the inclusion of racially, ethnically, and linguistically diverse subjects, with an emphasis on recruiting, retaining, and characterizing members of groups that historically have been under-represented in tissue banks and in research studies. This will help address the need for medical information and clinical specimens from subjects that are demographically and genetically representative of AIDS patients in the United States and elsewhere. b. The NNAB will collect information essential to study the effects of key co-morbid medical conditions such as hepatitis C virus (HCV) co-infection, hypertension, diabetes, lipid disorders, and other metabolic abnormalities associated with HIV and its treatment, on the development of HIV-associated neurological disease in our sample. c. The NNAB will develop a selectively recruited cohort of well-characterized HIV- comparison subjects to complement our HIV+ sample and to provide comparison tissues for research.