Neuroscience Cores For MR Studies of the Brain

用于大脑 MR 研究的神经科学核心

• 批准号: 7285707
• 负责人: KAMIL UGURBIL
• 金额: $ 156.76万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-08 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7285707
• 关键词: Neuroscience; Cores; MR; Studies; Brain

DESCRIPTION (provided by applicant): Especially since the introduction of functional magnetic resonance imaging (fMRI), a plethora of magnetic resonance (MR) techniques, such as neurochemical spectroscopy, perfusion imaging, imaging of vascular anatomy, diffusion imaging and functional imaging etc., have come to play an indispensable role in neurosciences. Furthermore, many of these methodologies, even at ultrahigh fields such as 7 Tesla, are rapidly moving from the domain of technique development carried out by MR physicist to become an indispensable tool employed routinely by a community of neuroscience researchers without expertise in MR physics. Contemporary use of such MR methodologies in neuroscience research requires immense auxiliary support that includes complex animal surgery, invasive infusions in humans and animal model studies, large scale data and image processing, and complementary non-MR measurements (e.g. electrophysiology, optical imaging, histology etc.). The aim of this proposal is to establish Neuroscience CORE facilities that will augment the existing state-of-the art and unique MR instrumentation resources located in the Center for Magnetic Resonance Research (CMRR) at the University of Minnesota, so as to enable access and utilization of CMRR,A6s resources by a large community of neuroscience researchers, and maximize the impact of modern MR techniques in neuroscience discovery.

描述（申请人提供）：特别是自从功能磁共振成像（fMRI）出现以来，神经化学波谱、灌注成像、血管解剖成像、扩散成像和功能成像等多种磁共振（MR）技术在神经科学中发挥着不可或缺的作用。 此外，许多这些方法，即使是在 7 特斯拉等超高场，也正在迅速从 MR 物理学家进行的技术开发领域转变为缺乏 MR 物理学专业知识的神经科学研究人员群体常规使用的不可或缺的工具。 当前在神经科学研究中使用此类 MR 方法需要巨大的辅助支持，包括复杂的动物手术、人类和动物模型研究中的侵入性输注、大规模数据和图像处理以及补充的非 MR 测量（例如电生理学、光学成像、组织学等）。 该提案的目的是建立神经科学核心设施，以增强明尼苏达大学磁共振研究中心 (CMRR) 现有的最先进和独特的 MR 仪器资源，以便让广大神经科学研究人员能够访问和利用 CMRR,A6s 资源，并最大限度地发挥现代 MR 技术在神经科学发现中的影响。