Keystone Symposia Meetings on NK and NKT Cell Biology and Innate Immunity

NK 和 NKT 细胞生物学和先天免疫 Keystone 研讨会

• 批准号: 7407677
• 负责人: ANDREW D ROBERTSON
• 金额: $ 1万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-01-15 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7407677
• 关键词: Area; Autoimmunity; B-Lymphocytes; Biology; Cells; Cellular biology; Collaborations; Colorado; Data; Diagnostic; Disease; Family; Fostering; Host Defense; Immune; Immune response; Infection; Inflammatory; Lead; Mediating; Molecular; Natural Immunity; Natural Killer Cells; Nature; Pathogenesis; Play; Protein Kinase; Proteins; Research; Research Personnel; Role; Shapes; Signal Transduction; T-Lymphocyte; Time; Toll-like receptors; Tumor Immunity; Work; abstracting; adapter protein; base; cell type; defense response; drug development; immunopathology; insight; interest; microbial; pathogen; prevent; receptor; response; symposium; transcription factor; tumor

ABSTRACT This proposal is to request support for a pair of concurrent 2008 Keystone Symposia meetings entitled "NK and NKT Cell Biology" (organized by Michael B. Brenner and Lewis L. Lanier), and "Innate Immunity: Signaling Mechanisms" (organized by Luke A.J. O'Neill, J¿rg Tschopp and Shizuo Akira), which will be held in Keystone, Colorado from February 24 - 29, 2008. NK cells and NKT cells play a central role in orchestrating and amplifying the innate response - and in shaping the nature of the adaptive response of T cells and B cells. The NK and NKT Cell Biology meeting will bring together, for the first time, researchers focusing on NK cells and NKT cells. This should initiate discussions, foster collaborations and lead to a better understanding how these cells use independent recognition mechanisms to achieve common effector functions and work coordinately to mediate immune responses against tumors and pathogens, as well as influence autoimmunity. With regard to the meeting on Innate Immunity: Signaling Mechanisms, the past 5 years has seen remarkable progress in our understanding of the molecular basis for innate immunity. New families of receptors have been discovered that sense microbial products, including Toll-like receptors (TLRs), NOD-like receptors (NLRs) and RIG-I-like receptors. In addition, signaling mechanisms activated by these receptor families have been described, with new adapter proteins, protein kinases and transcription factors being found. Breakthroughs in our understanding of signaling mechanisms is a key aspect for this field, with much excitement and insight being generated. This Keystone Symposia meeting will assemble the world's leading investigators in cell signaling during innate immunity, to present recent data and discuss the importance of signaling in the more general context of innate immunity. We can expect a compelling and informative meeting that will bring together basic researchers in the area but also those more generally interested in leading edge research in innate immunity. The pairing of these two Keystone Symposia meetings will stimulate productive interactions between experts in the areas of NK/NKT biology and innate immunity.

摘要 这项建议是请求支持2008年同时举行两次题为“北朝鲜和 NKT细胞生物学”（由Michael B组织。Brenner和刘易斯L. Lanier）和“先天免疫：信号传导 机制”（由Luke A. J.奥尼尔、J ² rg Tschopp和Shizuo Akira组织），将在基斯通举行， 2008年2月24日至29日，科罗拉多。NK细胞和NKT细胞在协调和治疗中发挥核心作用。 放大先天性反应-以及塑造T细胞和B细胞的适应性反应的性质。 NK和NKT细胞生物学会议将首次汇集专注于NK细胞的研究人员 NKT细胞。这将启动讨论，促进合作，并导致更好地了解如何 这些细胞使用独立的识别机制来实现共同的效应器功能和工作， 协同介导针对肿瘤和病原体的免疫应答，以及影响自身免疫。 关于先天免疫：信号传导机制会议，过去5年来， 我们对先天免疫的分子基础的理解取得了进展。新的受体家族已经 发现感觉微生物产物，包括Toll样受体（TLR），NOD样受体（NLR）和 RIG-I样受体。此外，由这些受体家族激活的信号传导机制已被证实是一种重要的信号传导机制。 新的衔接蛋白、蛋白激酶和转录因子被发现。 我们对信号机制的理解是这个领域的一个关键方面， 正在生成。这次Keystone研讨会会议将聚集世界领先的细胞研究人员， 信号在先天免疫，目前最新的数据，并讨论信号的重要性，在更多的 先天免疫的一般背景。我们可以期待一个引人注目和信息丰富的会议， 该领域的基础研究人员以及那些对前沿研究更感兴趣的人， 先天免疫这两个Keystone专题讨论会会议的配对将促进富有成效的互动 NK/NKT生物学和先天免疫领域的专家之间的合作。