Genetic damage in the sperm and blood of workers exposed to benzene

接触苯的工人精子和血液的基因损伤

基本信息

  • 批准号:
    7388869
  • 负责人:
  • 金额:
    $ 5.87万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2007
  • 资助国家:
    美国
  • 起止时间:
    2007-04-01 至 2010-03-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Evidence for male-mediated developmental toxicity derives from strong animal data and epidemiological studies, in which exposures of fathers to toxicants are associated with adverse consequences for the fetus and offspring. There is a strong paternal contribution for de novo gene mutations, sex chromosomal aneuploidies and structural aberrations in offspring. The purposes of this study are to examine the effects of benzene, a well-recognized mutagen, on DNA and chromosomal damage in human sperm and to determine the association between chromosomal damage in sperm and blood cells within the same individuals. Although there are a few previous sperm studies on benzene-exposed workers, they are small, have not controlled for potential confounders, and have included highly-exposed workers. In 2004, we conducted the China Benzene and Sperm Study (C-BASS) under the auspices of a prior Superfund grant. We have collected all biologic and environmental samples, including urine, blood, and semen samples and personal air badge monitors, and questionnaire data on 78 workers. Additionally, all sperm and blood genetic assays, including FISH for aneuploidy (X-Y-21), ACM, sperm Comet, Sperm Chromatin Structure Assay (SCSA), and OctoChrome FISH will be completed by June 2006. Delays due to the SARS epidemic in China prevented the earlier initiation and hence, the completion of the data analyses. The specific aims of this project are:1) to determine whether benzene-exposed Chinese workers (n=34) have higher frequencies of sperm with numerical and structural chromosomal defects compared to unexposed Chinese workers (n=34), and to determine if this relationship is dose-related to benzene exposure; 2) to determine whether the same benzene-exposed Chinese workers have more sperm with DNA fragmentation and DNA breaks compared to unexposed workers and to determine if this relationship is dose- related to benzene exposure; and 3) to determine whether benzene-exposed workers compared to unexposed workers have higher frequencies of aneuploidy and aberrations in lymphocytes and whether these chromosomal abnormalities are associated with similar defects in sperm. This project will contribute towards understanding the reproductive health of men exposed to benzene, by understanding whether benzene exposure is associated with production of a higher frequency of genetically- defective sperm and, indirectly, with the potential for an increased risk for paternally-mediated developmental effects in offspring. We will also add to the body of information necessary for risk assessment by determining whether benzene exposures represent a risk at doses nearer to those that are permissible in US workers than examined in previous studies. Lastly, this study is one of the first to investigate the relative sensitivities of sperm and blood cells to chromosomal defects induced by benzene.
描述(由申请方提供):雄性介导的发育毒性的证据来自强有力的动物数据和流行病学研究,其中父亲暴露于毒物与胎儿和后代的不良后果相关。子代中的从头基因突变、性染色体非整倍性和结构畸变有很强的父系贡献。本研究的目的是检查苯(一种公认的诱变剂)对人类精子DNA和染色体损伤的影响,并确定同一个体内精子和血细胞染色体损伤之间的关联。虽然之前有一些关于苯暴露工人的精子研究,但这些研究规模较小,没有控制潜在的混杂因素,并且包括高度暴露的工人。2004年,我们在超级基金的资助下进行了中国苯和精子研究(C-BASS)。我们收集了78名工人的所有生物和环境样本,包括尿液、血液和精液样本以及个人空气徽章监测器和问卷调查数据。此外,所有的精子和血液遗传检测,包括非整倍体FISH(X-Y-21)、ACM、精子彗星、精子染色质结构检测(SCSA)和精子染色质FISH,将于2006年6月完成。由于SARS在中国的流行而导致的延迟阻止了数据分析的早期启动,因此无法完成。本项目的具体目的是:1)确定苯暴露的中国工人(n=34)与未暴露的中国工人(n=34)相比是否具有更高频率的具有数量和结构染色体缺陷的精子,并确定这种关系是否与苯暴露剂量相关; 2)确定相同的苯暴露的中国工人与未暴露的工人相比是否具有更多的具有DNA片段化和DNA断裂的精子,并确定这种关系是否与苯暴露剂量相关;和3)确定苯接触工人与未接触工人相比是否具有更高的淋巴细胞非整倍体和畸变频率,以及这些染色体异常是否与精子中类似的缺陷有关。该项目将有助于了解接触苯的男性的生殖健康,了解苯接触是否与产生更高频率的遗传缺陷精子有关,以及间接地与后代中父亲介导的发育影响风险增加有关。我们还将增加风险评估所需的信息,确定苯暴露是否代表风险,其剂量比以前的研究更接近美国工人的允许剂量。最后,这项研究是第一个调查精子和血细胞对苯诱导的染色体缺陷的相对敏感性。

项目成果

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Brenda Eskenazi其他文献

Brenda Eskenazi的其他文献

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{{ truncateString('Brenda Eskenazi', 18)}}的其他基金

Maintaining and Expanding the CHAMACOS Epidemiology Cohort Infrastructure for Future Generations
为子孙后代维护和扩展 CHAMACOS 流行病学队列基础设施
  • 批准号:
    10166467
  • 财政年份:
    2017
  • 资助金额:
    $ 5.87万
  • 项目类别:
Maintaining and Expanding the CHAMACOS Epidemiology Cohort Infrastructure for Future Generations
为子孙后代维护和扩展 CHAMACOS 流行病学队列基础设施
  • 批准号:
    10200041
  • 财政年份:
    2017
  • 资助金额:
    $ 5.87万
  • 项目类别:
Maintaining and Expanding the CHAMACOS Epidemiology Cohort Infrastructure for Future Generations
为子孙后代维护和扩展 CHAMACOS 流行病学队列基础设施
  • 批准号:
    9385623
  • 财政年份:
    2017
  • 资助金额:
    $ 5.87万
  • 项目类别:
COVID-19 Pandemic among low-income Latino families in an agricultural community: Financial, occupational, and mental and physical health sequelae
COVID-19 在农业社区低收入拉丁裔家庭中的流行:财务、职业、精神和身体健康后遗症
  • 批准号:
    10176043
  • 财政年份:
    2016
  • 资助金额:
    $ 5.87万
  • 项目类别:
Long-term sequelae of early life pesticide exposure in the CHAMACOS birth cohort
CHAMACOS 出生队列中生命早期接触农药的长期后遗症
  • 批准号:
    9263646
  • 财政年份:
    2016
  • 资助金额:
    $ 5.87万
  • 项目类别:
Effect of early life exposure to social adversity and pesticides on risk-taking behavior of 16-18 year olds: the CHAMACOS study
早年接触社会逆境和农药对 16-18 岁青少年冒险行为的影响:CHAMACOS 研究
  • 批准号:
    9770856
  • 财政年份:
    2016
  • 资助金额:
    $ 5.87万
  • 项目类别:
Long-term sequelae of early life pesticide exposure in the CHAMACOS birth cohort
CHAMACOS 出生队列中生命早期接触农药的长期后遗症
  • 批准号:
    9355747
  • 财政年份:
    2016
  • 资助金额:
    $ 5.87万
  • 项目类别:
Effect of early life exposure to social adversity and pesticides on risk-taking behavior of 16-18 year olds: the CHAMACOS study
早年接触社会逆境和农药对 16-18 岁青少年冒险行为的影响:CHAMACOS 研究
  • 批准号:
    10018517
  • 财政年份:
    2016
  • 资助金额:
    $ 5.87万
  • 项目类别:
Long-term sequelae of early life pesticide exposure in the CHAMACOS birth cohort
CHAMACOS 出生队列中生命早期接触农药的长期后遗症
  • 批准号:
    9899747
  • 财政年份:
    2016
  • 资助金额:
    $ 5.87万
  • 项目类别:
Effect of early life exposure to social adversity and pesticides on risk-taking behavior of 16-18 year olds: the CHAMACOS study
早年接触社会逆境和农药对 16-18 岁青少年冒险行为的影响:CHAMACOS 研究
  • 批准号:
    9356508
  • 财政年份:
    2016
  • 资助金额:
    $ 5.87万
  • 项目类别:

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