IMAGING AND METROLOGY OF FLOW DYNAMICS IN MEMS MICROFLUIDIC CHANNEL

MEMS 微流道中流动动力学的成像和计量

• 批准号: 7722502
• 负责人: ZHONGPING CHEN
• 金额: $ 3.85万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-15 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7722502
• 关键词: Algorithms; Biological; Blood; Classification; Computer Retrieval of Information on Scientific Projects Database; Computer software; Computer-Aided Design; Data; Databases; Depth; Development; Engineering; Funding; Grant; Image; Institution; Liquid substance; Microfluidics; Modeling; Research; Research Personnel; Resources; Source; System; Technology; United States National Institutes of Health; evaluation/testing; fluid flow; metrology; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This proposal outlines two development efforts which are key to the intelligent integration of multi-component technologies in microfluidic systems, and of great importance to the maturation of microfluidics engineering and manufacturing in general. These are the development of a sophisticated, automated microfluidic probe station, and the subsequent use of that tool for the systematic study of non-ideal, non-homogeneous biological fluids such as blood in microfluidic chips. The probe station technology will allow for automated, high throughput testing and evaluation of microfluidic chips during and after manufacturing. The in-depth fluidics study will provide a better understanding of non-ideal, non-homogeneous fluid flow in common chip components by providing the experimental data needed for perfecting accurate modeling algorithms and providing databases needed for the ¿device libraries¿ of computer aided design software. This important study would not be possible without the development of the automated microfluidic probe station.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该提案概述了两项开发工作，这是微流体系统中多组分技术智能集成的关键，对微流体工程和制造的成熟具有重要意义。这些是一个复杂的，自动化的微流体探针站的发展，以及随后使用该工具的系统研究的非理想的，非均匀的生物流体，如血液在微流体芯片。探针台技术将允许在制造期间和之后对微流体芯片进行自动化、高通量测试和评估。深入的流体学研究将通过提供完善精确建模算法所需的实验数据和提供计算机辅助设计软件的设备库所需的数据库，更好地了解常见芯片组件中的非理想、非均匀流体流动。如果没有自动化微流体探针站的发展，这项重要的研究将是不可能的。