IMAGING AND METROLOGY OF FLOW DYNAMICS IN MEMS MICROFLUIDIC CHANNEL

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该提案概述了两项开发工作，这两项工作是微流控系统中多组分技术智能集成的关键，对微流控工程和制造的成熟具有重要意义。这些是开发一种复杂的自动化微流控探针站，并随后使用该工具对微流控芯片中的血液等非理想、非均一生物流体进行系统研究。探针站技术将允许在制造过程中和之后对微流控芯片进行自动化、高通量测试和评估。深入的流体学研究将提供完善精确建模算法所需的实验数据，并为计算机辅助设计软件的设备库提供所需的数据库，从而更好地了解常见芯片组件中的非理想、非均匀流体流动。如果没有自动微流控探针站的发展，这项重要的研究是不可能的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This proposal outlines two development efforts which are key to the intelligent integration of multi-component technologies in microfluidic systems, and of great importance to the maturation of microfluidics engineering and manufacturing in general. These are the development of a sophisticated, automated microfluidic probe station, and the subsequent use of that tool for the systematic study of non-ideal, non-homogeneous biological fluids such as blood in microfluidic chips. The probe station technology will allow for automated, high throughput testing and evaluation of microfluidic chips during and after manufacturing. The in-depth fluidics study will provide a better understanding of non-ideal, non-homogeneous fluid flow in common chip components by providing the experimental data needed for perfecting accurate modeling algorithms and providing databases needed for the ¿device libraries¿ of computer aided design software. This important study would not be possible without the development of the automated microfluidic probe station.