HUMAN NEUROBLASTOMA GLYCOPROTEINS EXPRESSING HNK-1 EPITOPE

表达 HNK-1 表位的人神经母细胞瘤糖蛋白

• 批准号: 7722629
• 负责人: J. Michael Pierce
• 金额: $ 0.38万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-08 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7722629
• 关键词: Cell Adhesion; Cell physiology; Computer Retrieval of Information on Scientific Projects Database; Epitopes; Funding; Glycoproteins; Grant; Human; Institution; Neuroblastoma; Neurons; Polysaccharides; Research; Research Personnel; Resources; Source; United States National Institutes of Health; enzyme activity; glycosyltransferase; migration

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. TThe HNK-1 epitope is expressed in neuronal cells and functions in cell adhesion. The synthesis of this epitope is believed to be dependent on the branched glycan synthesized by the glycosyltransferase GnT-VB. Modulation of the activity of this enzyme causes significant changes in neuroblastoma cell adhesion, migration, and invasiveness. Identification of the glycoproteins involved in these functions is critical for understanding glycan function.

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