课题基金 / 基金详情

Training in Bioenergetics, Oxidative Stress and Metabolic Syndrome

Training in Bioenergetics, Oxidative Stress and Metabolic Syndrome
生物能量学、氧化应激和代谢综合征培训
批准号:
8667109
负责人:
John J Lemasters
金额:
$10.16万
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-05-01 至 2019-04-30

项目摘要

项目成果

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中文摘要
翻译
这是一个旨在培训生物能量学研究的博士后和博士后科学家的项目, 氧化应激与代谢综合征(S)。它的目标是培养有才华的年轻人 在基础研究和临床研究领域,教他们如何设计和实施成功的 研究项目,并为科学研究的伦理和方法提供了坚实的背景。这个 我们奖学金的目标是增加对代谢综合征、生物能量学和 南卡罗来纳医科大学(MUSC)内的氧化应激并训练个人成为 代谢综合征及相关疾病领域的独立调查人员。学员将被挑选出来 从一大群候选人中选出。将特别努力识别少数族裔申请者。《BOMS》 该计划将分别为博士后和博士后提供长达三年和两年的支持 研究员与一大群才华横溢的教师导师一起工作。研究项目集中在以下领域 生物能量学和氧化应激与代谢综合征的各个方面有关,包括 胰岛素抵抗、糖尿病、肥胖、血脂异常、肝脏脂肪变性、炎症和随之而来的组织 受伤。每周与受训者举行会议,使他们能够向研究界介绍他们的材料。 此外,受训人员还需要在部门内部研讨会上展示他们的研究成果和兴趣。 小组会议,并向国家会议提交摘要。博士前学生将通过 研究生院,并按照生物医学博士的课程学习。收到后 细胞、分子和生物生物学方面的基本培训,博士前实习生将参加研究生 生物能量学和氧化应激课程,特别是与代谢综合征有关的课程。所有实习生都将 参加“负责任的研究行为”、“临床研究的方法”和“统计学”等课程 生物医学研究方法“。学员亦有机会修读有关生物医学研究的研究生课程。 南加州大学提供的各种研究课题,以增强他们的培训经验。督导委员会 将协助项目主管招募和挑选受训人员,批准研究和教学 制定计划,将受训人员分配到研究培训学院,并监督计划活动。内部和 外部咨询委员会将对培训计划进行额外评估,并向 指导委员会和项目总监。研究培训学院由资深研究人员组成, 目前在美国国立卫生研究院或其他校外资助,并且是经验丰富的导师。教职员工有不同的兴趣, 允许多名候选人在培训计划中找到合适的导师。额外的临床医生- 科学家导师将通过讨论临床方面的问题为学员提供指导 研究。海量的科研资源、医学科研资源和临床资源为 培训年轻的研究人员,他们将成为代谢综合征领域的未来院士。
英文摘要
This is a program designed to train pre- and post-doctoral scientists in research on Bioenergetics, Oxidative Stress and Metabolic Syndrome(s) (BOSMS). Its goals are to nurture talented young individuals in the areas of basic research and clinical investigation, teach them the design and conduct of successful research projects, and provide a solid background in the ethics and methods of scientific research. The objective of our fellowships is to increase the focus of research on metabolic syndrome, bioenergetics and oxidative stress within the Medical University of South Carolina (MUSC) and to train individuals to become independent investigators in the area of metabolic syndrome and related diseases. Trainees will be selected from a broad group of candidates. Special efforts will be made to identify minority applicants. The BOSMS program will provide up to three and two years of support, respectively, for predoctoral and postdoctoral fellowsworking with a large group of talented faculty mentors. Research projects are concentrated in the areas of bioenergetics and oxidative stress as they relate to various aspects of the metabolic syndrome, including insulin resistance, diabetes, obesity, dyslipidemia, hepatic steatosis, inflammation and consequent tissue injury. Weekly conferences with the trainees allow them to present their material to the research community. Additionally, trainees are required to present their research at in-house departmental seminars and interest group meetings and to submit abstracts to national meetings. Predoctoral students will matriculate through the College of Graduate Studies and follow the course of study for the PhD in Biomedical Sciences. After receiving basic training in cell, molecular and organismal biology, predoctoral trainees will participate in graduate courses on bioenergetics and oxidative stress especially in relation to the metabolic syndrome. All trainees will attend courses on "Responsible Conduct of Research", "Methods in Clinical Research", and "Statistical Methods in Biomedical Research". Trainees will also have the opportunity to attend graduate level courses on a variety of research topics available at MUSC to enhance their training experience. The Steering Committee will assist the Program Director in recruitment and selection of trainees, approval of research and didactic plans, assignment of trainees to Research Training Faculty, and monitoring of program activities. Internal and External Advisory Committees will provide additional evaluation of the training program and feedback to the Steering Committee and Program Director. Research Training Faculty are established investigators with current NIH or other extramural funding and are experienced mentors. The faculty has diverse interests, allowing multiple candidates to find appropriate mentors within the training program. Additional Clinician- Scientist mentors will provide guidance to trainees through discussion of the clinical dimensions of the research. The large number of research resources MUSC and clinical resources offer a rich environment for the training of young investigators who will become future academicians in the area of metabolic syndrome.
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会议论文
Cell and Molecular Imaging Core
Mechanisms of Mitochondrial Iron Uptake: New Therapeutic Targets in Hepatotoxicity
Mechanisms of Mitochondrial Iron Uptake: New Therapeutic Targets in Hepatotoxicity
Cell and Molecular Imaging Core
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