ESTIMATES OF HERITABILITY COEFFICIENTS IN FEMALE RHESUS MACAQUES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 背景：对圈养恒河猴(Macaca Mulatta)进行了一项研究，以估计一些生殖参数的遗传力。方法：收集1970年至2008年印度恒河猴群体的生殖记录。在此期间，共有3,569名女性创造了16,006份出生记录。记录包括女性和婴儿的身份识别，但不包括婴儿的男性父母。所有的生殖记录都被认为是女性基因的函数。因此，识别每个女性的水坝导致了以大水坝为共同父母的母系半同胞家庭。数据集中总共发现了1300座大坝。共有来自2,081座大坝的9,010条记录被确认为大坝。结果/讨论：每个大坝反应的统计模型包括作为随机变异源的大大坝和被发现影响特定反应变化的各种固定变异源。每个遗传力估计的标准误差是使用32*H2/N来确定的，其中N是针对该性状分析的记录数，32*H2/N是遗传力的方差估计。 终生生产力的遗传力系数适中。这些数据包括女性的死亡年龄(h2=0.60？0.11)、她最后一次出生时的年龄(h2=0.68？0.12)以及在她有生之年所生婴儿的数量(h2=0.61？0.11)。而产后初产年龄(h2=0.24？0.06)、出生间隔(h2=0.15？0.03)、婴儿存活30天(h2=0.14？0.02)和1岁(h2=0.06？0.02)等性状的遗传力系数很低。结合行为数据的遗传力估计可能为繁育群体的管理提供有用的工具，特别是对于繁育雌性的选择和保留。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: A study was conducted on captive rhesus macaque (Macaca mulatta) to estimate heritability of a number of reproductive parameters. Methods: Reproductive records from a colony of Indian rhesus macaques were available from the years 1970 to 2008. A total of 3,569 females produced 16,006 birth records during this period. Records included identification of female and infant, but not the male parent of the infant. All reproductive records were assumed to be a function of the female genotype. Therefore, identification of the dam of each female resulted in maternal half-sib families with the grand dam as the common parent. A total of 1,300 grand dams were identified in the data set. A total of 9,010 records from 2,081 dams had grand dam identification. Results/Discussion: The statistical model for each dam response included grand dam as a random source of variation and various fixed sources of variation that were found to influence variation in the particular response. The standard error of each heritability estimate was determined using 32*h2 /N where N is the number of records analyzed for that trait and 32*h2 /N is an estimate of the variance of heritability. Coefficients of heritability of lifetime productivity proved to be moderate. These included a female's age at death (h2 = 0.60¿ 0.11), her age at her last birth (h2 = 0.68 ¿ 0.12) and the number of infants produced during her lifetime (h2 = 0.61 ¿ 0.11). In contrast, traits such as postpartum age at first birth (h2 = 0.24 ¿ 0.06), birth interval (h2 = 0.15 ¿ 0.03), survival of the infant to 30 days (h2 = 0.14 ¿ 0.02) and 1 year (h2 = 0.06 ¿ 0.02) had very low heritability coefficients. Heritability estimates in association with behavioral data may provide useful tools in management of breeding colonies, particularly for the selection and retention of breeding females.