ESTIMATES OF HERITABILITY COEFFICIENTS IN FEMALE RHESUS MACAQUES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 前言：我们扩大了我们的研究范围，以确定圈养雌性恒河猴(Macaca Mulatta)一些生殖参数的遗传力系数，以包括表型和遗传相关性。方法：用于估计遗传力系数和表型相关的数据包括7829名新生儿、1898名女性和1227名大水坝。婴儿出生于1982年至2007年。用MTDFREML动物模型程序估计遗传度。由于没有确定男性父母，分子关系矩阵包含了所有涉及母亲同父异母和女儿-母亲关系的女性。生殖特征包括第一个、第二个和最后一个婴儿出生时的女性年龄、死亡年龄、出生间隔、每名女性生育的婴儿数量和婴儿存活率。 结果/讨论：遗传力估计通常很小，从第一个婴儿出生后产后出生间隔的0.000？0.072到女性死亡年龄的0.325？0.143。对雌性长寿性状和生产力的遗传力的估计是中等大小的，比大多数生殖性状的遗传力大。出生婴儿数和死亡年龄之间的表型相关性从接近零到0.900(P0.01)不等。遗传相关性较小，标准差较大。这里报道的遗传力估计似乎是合理的，并倾向于与其他物种的生殖特征类似。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: We have expanded our study to determine heritability coefficients of a number of reproductive parameters of captive female rhesus macaques (Macaca mulatta) to include phenotypic and genetic correlations. Methods: The data used to estimate heritability coefficients and phenotypic correlations contained 7,829 births, 1,898 females and 1,227 grand dams. Infants were born from 1982 through 2007. The MTDFREML animal model program was used to estimate heritability. Because no male parents were identified, the numerator relationship matrix contained all females involving maternal half-sib and daughter-dam relationships. Reproductive traits included female age at the birth of the first, second and last infant, age at death, inter-birth intervals, number of infants born per female and infant survival. Results/Discussion: Heritability estimates were generally small, ranging from 0.000 ¿ 0.072 for postpartum birth interval following the birth of the first infant to 0.325 ¿ 0.143 for a female's age at death. Estimates for heritability for female longevity traits and for productivity were moderate in size and larger than for most reproductive traits. Phenotypic correlations varied from near zero to 0.900 (P 0.01) between number of infants born and dam age at death. Genetic correlations were small with large standard errors. The heritability estimates reported here appear reasonable and tend to be similar to those for reproductive traits in other species.